One-step assembly of CuMo2S3 nanocrystals for the synergistic effect of photothermal therapy and photodynamic therapy

被引：16
|
作者：
Huang, Zhi [1 ]
Liu, Xijian [1 ]
Deng, Guoying [2 ]
Yuan, Haikuan [1 ]
Wang, Qiugeng [2 ]
Zhang, Lijuan [1 ]
Lu, Jie [1 ]
机构：
[1] Shanghai Univ Engn Sci, Coll Chem & Chem Engn, Shanghai 201620, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Gen Hosp, Ctr Trauma, 650 Xin Songjiang Rd, Shanghai 201620, Peoples R China
来源：
DALTON TRANSACTIONS | 2018年 / 47卷 / 16期
基金：
中国国家自然科学基金;
关键词：
NEAR-INFRARED LIGHT; EFFICIENT ABLATION; W18O49; NANOWIRES; QUANTUM DOTS; TUMOR; NANOPLATFORM; CELLS; NANOPARTICLES; NANOMATERIALS; COMBINATION;
D O I：
10.1039/c7dt04901c
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
In this study, we fabricated a novel PVP conjugated CuMo2S3 nanocrystal, which can be used as an efficient photosensitizer. The CuMo2S3 nanocrystals were synthesized via a facile one-pot reflux method and exhibited high biocompatibility, strong NIR absorbance, low cytotoxicity, high stability, high photo thermal conversion efficiency, and effective generation of reactive oxygen species (ROS). Moreover, the combined treatments of photodynamic therapy (PDT) and photothermal therapy (PH) generated by the CuMo2S3 nanocrystals under NIR irradiation drastically inhibited tumor growth. Thus, CuMo2S3 nanocrystals have a great potential for synergistic effect of PDT and PTT.
引用
收藏
页码：5622 / 5629
页数：8
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