Evolution of the Helicobacter pylori vacuolating cytotoxin in a human stomach

被引：18

作者：

Aviles-Jimenez, F

Letley, DP

Gonzalez-Valencia, G

Salama, N

Torres, J

Atherton, JC ^{[1
]}

机构：

[1] Univ Nottingham Hosp, Wolfson Digest Dis Ctr, Nottingham NG7 2UH, England

[2] Univ Nottingham Hosp, Inst Infect Immun & Inflammat, Nottingham NG7 2UH, England

[3] IMSS, Mexico City, DF, Mexico

[4] Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98104 USA

来源：

JOURNAL OF BACTERIOLOGY | 2004年 / 186卷 / 15期

关键词：

D O I：

10.1128/jb.186.15.5182-5185.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We describe two subclones of Helicobacter pylori, isolated contemporaneously from a human stomach, which differ markedly in the vacuolating cytotoxin gene, vacA, but whose near identity in sequences outside this locus implies a very recent common origin. The differences are consistent with homologous recombination with DNA from another strain and result in a changed vacA midregion and, importantly, in changed toxicity.

引用

页码：5182 / 5185

页数：4

共 50 条

[41] The Helicobacter pylori vacuolating cytotoxin:: from cellular vacuolation to immunosuppressive activities
Gebert, B
Fischer, W
Haas, R
REVIEWS OF PHYSIOLOGY, BIOCHEMICAL AND PHARMACOLOGY, VOL 152, 2005, 152 : 205 - 220
[42] Human milk vacuolating cytotoxin A immunoglobulin A antibodies modify Helicobacter pylori infection in Gambian children
Campbell, D. I.
Bunn, J. E. G.
Weaver, L. T.
Harding, M.
Coward, W. A.
Thomas, J. E.
CLINICAL INFECTIOUS DISEASES, 2006, 43 (08) : 1040 - 1042
[43] Vacuolating cytotoxin purified from Helicobacter pylori causes mitochondrial damage in human gastric cells
Kimura, M
Goto, S
Wada, A
Yahiro, K
Niidome, T
Hatakeyama, T
Aoyagi, H
Hirayama, T
Kondo, T
MICROBIAL PATHOGENESIS, 1999, 26 (01) : 45 - 52
[44] Natural diversity in the N terminus of the mature vacuolating cytotoxin of Helicobacter pylori determines cytotoxin activity
Letley, DP
Atherton, JC
JOURNAL OF BACTERIOLOGY, 2000, 182 (11) : 3278 - 3280
[45] Vacuolating Cytotoxin A Triggers Mitophagy in Helicobacter pylori-Infected Human Gastric Epithelium Cells
Wang, Li
Yi, Juan
Yin, Xiao-Yang
Hou, Jin-Xia
Chen, Jing
Xie, Bei
Chen, Gang
Wang, Qun-Feng
Wang, Li-Na
Wang, Xiao-Yuan
Sun, Jing
Huo, Lei-Ming
Che, Tuan-Jie
Wei, Hu-Lai
FRONTIERS IN ONCOLOGY, 2022, 12
[46] Comparison of cytotoxin genotypes of Helicobacter pylori in stomach and saliva
Wang, J
Chi, DS
Laffan, JJ
Li, CF
Ferguson, DA
Litchfield, P
Thomas, E
DIGESTIVE DISEASES AND SCIENCES, 2002, 47 (08) : 1850 - 1856
[47] Comparison of Cytotoxin Genotypes of Helicobacter pylori in Stomach and Saliva
Jie Wang
David S. Chi
John J. Laffan
Chuanfu Li
Donald A. Ferguson
Peter Litchfield
Eapen Thomas
Digestive Diseases and Sciences, 2002, 47 : 1850 - 1856
[48] The interrelationship between cytotoxin-associated gene A, vacuolating cytotoxin, and Helicobacter pylori-related diseases
Weel, JFL
vanderHulst, RWM
Gerrits, Y
Roorda, P
Feller, M
Dankert, J
Tytgat, GNJ
vanderEnde, A
JOURNAL OF INFECTIOUS DISEASES, 1996, 173 (05): : 1171 - 1175
[49] The Versatility of the Helicobacter pylori Vacuolating Cytotoxin VacA in Signal Transduction and Molecular Crosstalk
Backert, Steffen
Tegtmeyer, Nicole
TOXINS, 2010, 2 (01) : 69 - 92
[50] Vacuolating cytotoxin A types and their role in Helicobacter pylori-mediated immunomodulation in vivo
Kaneko, K.
Reddiar, D.
Ogbodo, E. J.
Letley, D. P.
Rhead, J. L.
Atherton, J. C.
Robinson, K.
HELICOBACTER, 2017, 22

← 1 2 3 4 5 →