Dose-response effect of RPE65 gene therapy on retinoid levels and correlation with clinical rescue in Rpe65-deficient dogs

被引：0
|
作者：
Mowat, Freya [1 ,2 ]
Feathers, Kecia L. [3 ]
Smith, Alexander J. [2 ,4 ]
Thompson, Debra A. [3 ]
Petersen-Jones, Simon M. [1 ]
Bainbridge, James W. B. [2 ,4 ]
Ali, Robin R. [2 ,4 ]
机构：
[1] Michigan State Univ, Coll Vet Med, Small Anim Clin Sci, E Lansing, MI 48824 USA
[2] UCL Inst Ophthalmol, London, England
[3] Univ Michigan, Dept Biol Chem, Dept Ophthalmol & Visual Sci, Ann Arbor, MI 48109 USA
[4] Biomed Res Ctr Ophthalmol Moorfields, Natl Inst Hlth Res, London, England
来源：
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2015年 / 56卷 / 07期
关键词：
D O I：
暂无
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
2064
引用
收藏
页数：2
相关论文
共 50 条
  • [1] RPE65 gene therapy slows cone loss in Rpe65-deficient dogs
    Mowat, F. M.
    Breuwer, A. R.
    Bartoe, J. T.
    Annear, M. J.
    Zhang, Z.
    Smith, A. J.
    Bainbridge, J. W. B.
    Petersen-Jones, S. M.
    Ali, R. R.
    GENE THERAPY, 2013, 20 (05) : 545 - 555
  • [2] RPE65 gene therapy slows cone loss in Rpe65-deficient dogs
    F M Mowat
    A R Breuwer
    J T Bartoe
    M J Annear
    Z Zhang
    A J Smith
    J W B Bainbridge
    S M Petersen-Jones
    R R Ali
    Gene Therapy, 2013, 20 : 545 - 555
  • [3] Successful Gene Therapy in Older Rpe65-Deficient Dogs Following Subretinal Injection of an Adeno-Associated Vector Expressing RPE65
    Annear, Matthew J.
    Mowat, Freya M.
    Bartoe, Joshua T.
    Querubin, Janice
    Azam, Selina A.
    Basche, Mark
    Curran, Paul G.
    Smith, Alexander J.
    Bainbridge, James W. B.
    Ali, Robin R.
    Petersen-Jones, Simon M.
    HUMAN GENE THERAPY, 2013, 24 (10) : 883 - 893
  • [4] Gene therapy in the second eye of RPE65-deficient dogs improves retinal function
    M J Annear
    J T Bartoe
    S E Barker
    A J Smith
    P G Curran
    J W Bainbridge
    R R Ali
    S M Petersen-Jones
    Gene Therapy, 2011, 18 : 53 - 61
  • [5] Gene therapy in the second eye of RPE65-deficient dogs improves retinal function
    Annear, M. J.
    Bartoe, J. T.
    Barker, S. E.
    Smith, A. J.
    Curran, P. G.
    Bainbridge, J. W.
    Ali, R. R.
    Petersen-Jones, S. M.
    GENE THERAPY, 2011, 18 (01) : 53 - 61
  • [6] Gene therapy to abolish congenital nystagmus in RPE65-deficient canines
    Jacobs, JB
    Dell'Osso, LF
    Hertle, RW
    Bennett, J
    Acland, G
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2003, 44 : U479 - U479
  • [7] A Comprehensive Study of the Retinal Phenotype of Rpe65-Deficient Dogs
    Annear, Matthew J.
    Mowat, Freya M.
    Occelli, Laurence M.
    Smith, Alexander J.
    Curran, Paul G.
    Bainbridge, James W.
    Ali, Robin R.
    Petersen-Jones, Simon M.
    CELLS, 2021, 10 (01) : 1 - 16
  • [8] Retinal Disease in Rpe65-Deficient Mice: Comparison to Human Leber Congenital Amaurosis Due to RPE65 Mutations
    Caruso, Rafael C.
    Aleman, Tomas S.
    Cideciyan, Artur V.
    Roman, Alejandro J.
    Sumaroka, Alexander
    Mullins, Cristina L.
    Boye, Sanford L.
    Hauswirth, William W.
    Jacobson, Samuel G.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2010, 51 (10) : 5304 - 5313
  • [9] Gene Therapy in the Second Eye of RPE65 Deficient Dogs Rescues Retinal Function
    Annear, M. J.
    Bartoe, J. T.
    Barker, S. E.
    Smith, A. J.
    Curran, P. G.
    Bainbridge, J. W.
    All, R. R.
    Petersen-Jones, S. M.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2010, 51 (13)
  • [10] Positive results for RPE65 gene therapy
    Cunliffe, Rhian
    EXPERT REVIEW OF OPHTHALMOLOGY, 2008, 3 (03) : 259 - 259
12345