Malignant transformation of a vestibular schwannoma after gamma knife radiosurgery

被引：170
|
作者：
Shin, M [1 ]
Ueki, K [1 ]
Kurita, H [1 ]
Kirino, T [1 ]
机构：
[1] Tokyo Univ Hosp, Dept Neurosurg, Tokyo 113, Japan
来源：
LANCET | 2002年 / 360卷 / 9329期
关键词：
D O I：
10.1016/S0140-6736(02)09521-1
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Stereotactic radiosurgery is used to treat benign tumours, but its long-term effects are not fully understood. Here we describe a vestibular schwannoma that underwent malignant transformation 6 years after gamma knife radiosurgery applied to the tumour remnant after a primary resection. Histological specimens of the original specimen did not show any atypical features. Genotyping showed a TP53 mutation in the recurrent tumour, which did not exist in the original tumour. Our results suggest that radiosurgery induced the malignant transformation, and we propose a cautious application of this treatment for benign tumours.
引用
收藏
页码：309 / 310
页数：2
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