Prompt diagnosis and management of Epstein-Barr virus-associated post-transplant lymphoproliferative disorder and hemophagocytosis: A dreaded complication in a post-liver transplant child

被引：10

作者：

Jha, Bhawna ^{[1
]}

Mohan, Neelam ^{[1
]}

Gajendra, Smeeta ^{[1
]}

Sachdev, Ritesh ^{[1
]}

Goel, Shalini ^{[1
]}

Sahni, Tushar ^{[1
]}

Raina, Vimarsh ^{[1
]}

Soin, A. ^{[1
]}

机构：

[1] The Medicity, Medanta, Dept Pathol & Lab Med, Gurgaon 122001, Haryana, India

来源：

PEDIATRIC TRANSPLANTATION | 2015年 / 19卷 / 07期

关键词：

post-transplant lymphoproliferative disease; hemophagocytosis; liver transplant; RECIPIENTS; DISEASE; PATIENT;

D O I：

10.1111/petr.12558

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

EBV-associated PTLD is increasingly recognized as an important cause of morbidity and mortality in both solid organ and hematopoietic stem cell transplant recipients. Mortality rates due to PTLD and virus-induced HLH are reported to be quite high. We report a case of EBV-associated PTLD and HLH in a child after liver transplantation who was successfully managed due to timely intervention. This case highlights that measurement of EBV load by quantitative polymerase chain reaction assays is an important aid in the surveillance and diagnosis of PTLD and early detection of EBV-induced PTLD, and aggressive treatment with rituximab is a key to survival in patients who have undergone liver transplantation.

引用

页码：E177 / E180

页数：4

共 50 条

[41] Epstein-Barr virus gene expression in post-transplant lymphoproliferative disorders
Rowe, M
Niedobitek, G
Young, LS
SPRINGER SEMINARS IN IMMUNOPATHOLOGY, 1998, 20 (3-4): : 389 - 403
[42] Epstein-Barr virus associated with a post-transplant lymphoproliferative disorder presenting as isolated gastrointestinal tract bleeding
Badham, K.
Mirchandani, A.
Arumainayagam, N.
West, D. R.
ENDOSCOPY, 2007, 39 : E64 - E65
[43] CiclosporinPolymorphic post-transplant Epstein-Barr virus associated lymphoproliferative disorder with cutaneous involvement: case report
Reactions Weekly, 2019, 1781 (1) : 109 - 109
[44] Acute renal allograft rejection in patients with Epstein-Barr virus associated post-transplant lymphoproliferative disorder
Purighalla, R
Shapiro, R
Jordan, ML
Scantlebury, VP
Gritsch, HA
Vivas, C
Randhawa, PS
CLINICAL TRANSPLANTATION, 1997, 11 (06) : 574 - 576
[45] Endobronchial Epstein-Barr Virus Associated Post-transplant Lymphoproliferative Disorder in Hematopoietic Stem Cell Transplantation
Feuillet, S.
Meignin, V.
Briere, J.
Brice, P.
Rocha, V.
Socie, G.
Tazi, A.
Bergeron, A.
CLINICAL MEDICINE INSIGHTS-CASE REPORTS, 2009, 2 : 11 - 15
[46] Oral hairy leukoplakia as an early indicator of Epstein-Barr virus - Associated post-transplant lymphoproliferative disorder
Casiglia, J
Woo, SB
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2002, 60 (08) : 948 - 950
[47] Genomic Variations in Epstein Barr Virus are Associated with Post-Transplant Lymphoproliferative Disorder.
Arvedson, M.
Maloney, E.
Esquivel, C.
Martinez, O.
Krams, S.
AMERICAN JOURNAL OF TRANSPLANTATION, 2019, 19 : 1157 - 1157
[48] Recent advances in the risk factors, diagnosis and management of Epstein-Barr virus post-transplant lymphoproliferative disease
Aguayo-Hiraldo, Paibel
Arasaratnam, Reuben
Rouce, Rayne H.
BOLETIN MEDICO DEL HOSPITAL INFANTIL DE MEXICO, 2016, 73 (01): : 31 - 40
[49] Renal allograft involvement by Epstein-Barr virus associated post-transplant lymphoproliferative disease
Randhawa, PS
Magnone, M
Jordan, M
Shapiro, R
Demetris, AJ
Nalesnik, M
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1996, 20 (05) : 563 - 571
[50] Preemptive diagnosis and treatment of Epstein-Barr virus-associated post transplant lymphoproliferative disorder after hematopoietic stem cell transplant: an approach in development
Weinstock, DM
Ambrossi, GG
Brennan, C
Kiehn, TE
Jakubowski, A
BONE MARROW TRANSPLANTATION, 2006, 37 (06) : 539 - 546

← 1 2 3 4 5 →