Histone lysine demethylases in Drosophila melanogaster

被引：17

作者：

Holowatyj, Andreana ^{[1
,2
]}

Yang, Zeng-Quan ^{[1
,2
]}

Pile, Lori A. ^{[2
,3
]}

机构：

[1] Wayne State Univ, Sch Med, Dept Oncol, Detroit, MI USA

[2] Wayne State Univ, Sch Med, Karmanos Canc Inst, Detroit, MI 48202 USA

[3] Wayne State Univ, Dept Biol Sci, Detroit, MI 48202 USA

来源：

FLY | 2015年 / 9卷 / 01期

关键词：

chromatin; cancer; demethylase; Drosophila; Epigenetics; histone; JmjC domain; KDM; modifications; tumorigenesis; BREAST-CANCER; GENOMIC AMPLIFICATION; GENETIC SCREEN; H3; METHYLATION; CHROMATIN; TRANSCRIPTION; PROTEIN; NOTCH; JMJC;

D O I：

10.1080/19336934.2015.1074787

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epigenetic regulation of chromatin structure is a fundamental process for eukaryotes. Regulators include DNA methylation, microRNAs and chromatin modifications. Within the chromatin modifiers, one class of enzymes that can functionally bind and modify chromatin, through the removal of methyl marks, is the histone lysine demethylases. Here, we summarize the current findings of the 13 known histone lysine demethylases in Drosophila melanogaster, and discuss the critical role of these histone-modifying enzymes in the maintenance of genomic functions. Additionally, as histone demethylase dysregulation has been identified in cancer, we discuss the advantages for using Drosophila as a model system to study tumorigenesis.

引用

页码：36 / 44

页数：9

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