Enantioselective total synthesis of taxusin and taxol

被引：1

作者：

Kuwajima, I ^{[1
]}

Kusama, H ^{[1
]}

机构：

[1] Kitasato Inst, Biol Funct Res Ctr, Minato Ku, Tokyo 1088642, Japan

来源：

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN | 2000年 / 58卷 / 03期

关键词：

total synthesis; taxane diterpenoids; taxusin; taxol;

D O I：

10.5059/yukigoseikyokaishi.58.172

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aiming at the construction of taxane ABC tricarbocycles, a useful methodology including an aldol-like eight-membered B ring cyclization between dienol silyl ethers and acetals was explored. By applying this methodology, the enantioselective total synthesis of (+)-taxusin and (-)-taxol have been achieved, starting from the substrate containing a chiral center at each C1 site, based on AC to ABC strategies.

引用

页码：172 / 182

页数：11

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