APOE-ε4 predicts incident AD in Japanese-American men:: The Honolulu-Asia Aging Study

被引：52

作者：

Havlik, RJ

Izmirlian, G

Petrovitch, H

Ross, GW

Masaki, K

Curb, JD

Saunders, AM

Foley, DJ

Brock, D

Launer, LJ

White, L

机构：

[1] NIA, Epidemiol Demog & Biometry Program, NIH, Bethesda, MD 20892 USA

[2] Kuakini Med Ctr, Honolulu Asia Aging Study, Honolulu, HI USA

[3] Dept Vet Affairs, Honolulu, HI USA

[4] Univ Hawaii, John A Burns Sch Med, Dept Med, Honolulu, HI 96822 USA

[5] Duke Univ, Med Ctr, Joseph & Kathleen Bryan Alzheimers Dis Res Ctr, Dept Med Neurol, Durham, NC USA

来源：

NEUROLOGY | 2000年 / 54卷 / 07期

关键词：

dementia; risk factors; epidemiology;

D O I：

10.1212/WNL.54.7.1526

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors assessed the 3-year incidence of dementia, including subtypes, in 2,603 Japanese-American men 71 to 93 years of age who were dementia free at baseline. There were 137 new cases of dementia according to the Diagnostic and Statistical Manual of Mental Disorders, 3rd edition, revised, including 51 with a primary diagnosis of AD. The rates for all subtypes increased with age. Men with an APOE4 allele had a significantly increased risk of AD of 2.39 (95% CI, 1.07, 5.31), after adjusting for age and education. There was no significant relationship of APOE4 with other subtypes of dementia.

引用

页码：1526 / 1529

页数：4

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