Biomarkers of human gut microbiota diversity and dysbiosis

被引：8
|
作者：
Rueb, Alina M. [1 ]
Tsakmaklis, Anastasia [1 ]
Graefe, Stefanie K. [1 ]
Simon, Marie-Christine [2 ]
Vehreschild, Maria J. G. T. [3 ]
Wuethrich, Irene [4 ]
机构：
[1] Univ Hosp Cologne, Dept Internal Med 1, Cologne, Germany
[2] Univ Bonn, Dept Nutr & Food Sci, Nutr & Microbiota, Bonn, Germany
[3] Goethe Univ Frankfurt, Univ Hosp Frankfurt, Dept Internal Med Infect Dis, Frankfurt, Germany
[4] Swiss Fed Inst Technol, Dept Biosyst Sci & Engn, Basel, Switzerland
来源：
BIOMARKERS IN MEDICINE | 2021年 / 15卷 / 02期
关键词：
biomarker; diagnostics; disease marker; dysbiosis; gut microbiota; microbial diversity; microbial metabolites; microbiota; CHAIN FATTY-ACIDS; INTESTINAL MICROBIOTA; BILE-ACIDS; HIPPURATE HYDROLYSIS; EPITHELIAL-CELLS; INDOXYL SULFATE; METABOLISM; ZONULIN; IGA; BETA-DEFENSIN-2;
D O I：
10.2217/bmm-2020-0353
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The association of gut microbiota dysbiosis with various human diseases is being substantiated with increasing evidence. Metabolites derived from both, microbiota and the human host play a central role in disease susceptibility and disease progression by extensively modulating host physiology and metabolism. Several of these metabolites have the potential to serve as diagnostic biomarkers for monitoring disease states in conjunction with intestinal microbiota dysbiosis. In this narrative review we evaluate the potential of trimethylamine-N-oxide, short-chain fatty acids, 3-indoxyl sulfate, p-cresyl sulfate, secondary bile acids, hippurate, human beta-defensin-2, chromogranin A, secreted immunoglobulins and zonulin to serve as biomarkers for metabolite profiling and diagnostic suitability for dysbiosis and disease.
引用
收藏
页码：137 / 148
页数：12
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