Periadventitial adipose-derived stem cell treatment halts elastase-induced abdominal aortic aneurysm progression

被引：1
|
作者：
Blose, Kory J. [1 ]
Ennis, Terri L. [2 ]
Arif, Batool [2 ]
Weinbaum, Justin S. [1 ,3 ]
Curci, John A. [2 ,4 ]
Vorp, David A. [1 ,3 ,5 ,6 ,7 ]
机构：
[1] Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA 15260 USA
[2] Washington Univ, Sch Med, Dept Surg, Vasc Surg Sect, St Louis, MO 63110 USA
[3] Univ Pittsburgh, McGowan Inst Regenerat Med, Pittsburgh, PA USA
[4] Dept Vet Affairs Med Ctr, Surg Serv, John Cochran Div, St Louis, MO USA
[5] Univ Pittsburgh, Dept Cardiothorac Surg, Pittsburgh, PA USA
[6] Univ Pittsburgh, Dept Surg, Pittsburgh, PA USA
[7] Univ Pittsburgh, Ctr Vasc Remodeling & Regenerat, Pittsburgh, PA USA
来源：
REGENERATIVE MEDICINE | 2014年 / 9卷 / 06期
基金：
美国国家卫生研究院;
关键词：
abdominal aortic aneurysm; adipose-derived stem cells; elastin; regeneration; STROMAL CELLS; MOUSE MODEL; DOXYCYCLINE; DILATATION; EXPRESSION; THERAPIES; THROMBUS; TISSUE;
D O I：
10.2217/RME.14.61
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Aim: Demonstrate that periadventitial delivery of adipose-derived mesenchymal stem cells (ADMSCs) slows aneurysm progression in an established murine elastase-perfusion model of abdominal aortic aneurysm (AAA). Materials & methods: AAAs were induced in C57BL/6 mice using porcine elastase. During elastase perfusion, a delivery device consisting of a subcutaneous port, tubing and porous scaffold was implanted. Five days after elastase perfusion, 100,000 ADMSCs were delivered through the port to the aorta. After sacrifice at day 14, analyzed metrics included aortic diameter and structure of aortic elastin. Results: ADMSC treated aneurysms had a smaller diameter and less fragmented elastin versus saline controls. Conclusion: Periadventitial stem cell delivery prevented the expansion of an established aneurysm between days 5 and 14 after elastase perfusion.
引用
收藏
页码：733 / 741
页数：9
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