New compounds from the Red Sea marine sponge Echinoclathria gibbosa

被引：10
|
作者：
Mohamed, Gamal A. [1 ]
Abd-Elrazek, Ali E. E. [1 ]
Hassanean, Hashim A. [2 ]
Youssef, Diaa T. A. [2 ,3 ]
van Soest, Rob [4 ]
机构：
[1] Al Azhar Univ, Assiut Branch, Fac Pharm, Dept Pharmacognosy, Assiut 71524, Egypt
[2] Suez Canal Univ, Fac Pharm, Dept Pharmacognosy, Ismailia 41522, Egypt
[3] King Abdulaziz Univ, Fac Pharm, Dept Nat Prod & Alternat Med, Jeddah 21589, Saudi Arabia
[4] Nat Biodivers Ctr, Dept Marine Zool, NL-2300 RA Leiden, Netherlands
来源：
PHYTOCHEMISTRY LETTERS | 2014年 / 9卷
关键词：
Echinoclathria gibbosa; Pregnane; Ceramide; Anti-inflammatory; Hepato-protective; Cancer growth inhibitory activity; A-C; CONSTITUENTS; CERAMIDES; ALKALOIDS; GLYCOSIDE;
D O I：
10.1016/j.phytol.2014.04.008
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Three new compounds; beta-sitosterol-3-O-(3Z)-pentacosenoate (1), 5 alpha-pregna-3 beta-acetoxy-12 beta, 16 beta-diol-20-one (2), and echinoclathriamide ((R)-2'-hydroxy-N-((2S, 3S, 4R)-1,3,4-trihydroxy-19-methylicosan-2-yl) heptadecanamide) (3), together with two known compounds; thymine (4) and uracil (5) were isolated from the EtOAc fraction of the Red Sea sponge Echinoclathria gibbosa. Their structures were unambiguously established on the basis of 1D and 2D NMR spectroscopy, in addition to mass spectrometry. The total MeOH extract (TME) and its fractions were evaluated for their antimicrobial, anti-inflammatory, antipyretic, and hepato-protective activities. The in vitro growth inhibitory activity of the isolated compounds was evaluated against three human cancer cell lines including the A549 non-small cell lung cancer (NSCLC), U373 glioblastoma (GBM), and PC-3 prostate cancer cell lines. Compound 1 showed weak activity against the three cancer cell lines. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：51 / 58
页数：8
相关论文
共 50 条
  • [31] New Cytotoxic Natural Products from the Red Sea Sponge Stylissa carteri
    Abdelhameed, Reda F. A.
    Habib, Eman S.
    Eltahawy, Nermeen A.
    Hassanean, Hashim A.
    Ibrahim, Amany K.
    Mohammed, Anber F.
    Fayez, Shaimaa
    Hayallah, Alaa M.
    Yamada, Koji
    Behery, Fathy A.
    Al-Sanea, Mohammad M.
    Alzarea, Sami, I
    Bringmann, Gerhard
    Ahmed, Safwat A.
    Abdelmohsen, Usama Ramadan
    MARINE DRUGS, 2020, 18 (05)
  • [32] Chagosensine, a new chlorinated macrolide from the Red Sea sponge Leucetta chagosensis
    Rezanka, T
    Hanus, L
    Dembitsky, VM
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2003, 2003 (20) : 4073 - 4079
  • [33] NEW PENTACYCLIC COMPOUNDS FROM THE OKINAWAN MARINE SPONGE XESTOSPONGIA-SAPRA
    KOBAYASHI, J
    HIRASE, T
    SHIGEMORI, H
    ISHIBASHI, M
    BAE, MA
    TSUJI, T
    SASAKI, T
    JOURNAL OF NATURAL PRODUCTS, 1992, 55 (07): : 994 - 998
  • [34] Two new compounds from the marine sponge derived fungus Penicillium chrysogenum
    Han, Xiao
    Li, Pinglin
    Luo, Xiangchao
    Qiao, Dan
    Tang, Xuli
    Li, Guoqiang
    NATURAL PRODUCT RESEARCH, 2020, 34 (20) : 2926 - 2930
  • [35] Dipuupehedione, a cytotoxic new red dimer from a New Caledonian marine sponge Hyrtios sp
    BourguetKondracki, ML
    Debitus, C
    Guyot, M
    TETRAHEDRON LETTERS, 1996, 37 (22) : 3861 - 3864
  • [36] NEW TETRAHYDROPYRANS FROM A MARINE SPONGE
    CAPON, RJ
    GHISALBERTI, EL
    JEFFERIES, PR
    TETRAHEDRON, 1982, 38 (11) : 1699 - 1703
  • [37] Latrunculin U: a potent actin-disrupter from the Red Sea marine sponge Negombata magnifica
    Youssef, Diaa T. A.
    Alommary, Mohamed M.
    Bashanfar, Bushra M.
    Shaala, Lamiaa A.
    Alzughaibi, Torki A.
    Risinger, April L.
    Mooberry, Susan L.
    NATURAL PRODUCT RESEARCH, 2025,
  • [38] Anti-choline esterase activity of ceramides from the Red Sea marine sponge Mycale euplectellioides
    Abdelhameed, Reda
    Elgawish, Mohamed Saleh
    Mira, Amira
    Ibrahim, Amany K.
    Ahmed, Safwat A.
    Shimizu, Kuniyoshi
    Yamada, Koji
    RSC ADVANCES, 2016, 6 (24): : 20422 - 20430
  • [39] Hyrtiazepine, an azepino-indole-type alkaloid from the Red Sea marine sponge Hyrtios erectus
    Sauleau, Pierre
    Martin, Marie-Therese
    Dau, Marie-Elise Tran Huu
    Youssef, Diaa T. A.
    Bourguet-Kondracki, Marie-Lise
    JOURNAL OF NATURAL PRODUCTS, 2006, 69 (12): : 1676 - 1679
  • [40] A new diketopiperazine from South China Sea marine sponge Callyspongia sp.
    Chen, Yinning
    Peng, Yan
    Gao, Chenghai
    Huang, Riming
    NATURAL PRODUCT RESEARCH, 2014, 28 (13) : 1010 - 1014
12345