Synthesis of 9-[2',3'-dideoxy-2',3'-bis-C-hydroxymethyl-alpha-L-threofuranosyl] adenine and its 4'-thio analog as potential antiviral agents

被引：13
|
作者：
Kikuchi, Y
Kurata, H
Nishiyama, S
Yamamura, S
Kato, K
机构：
[1] NIPPON KAYAKU CO LTD,PHARMACEUT GRP,RES LABS,KITA KU,TOKYO 115,JAPAN
[2] KEIO UNIV,FAC SCI & TECHNOL,DEPT CHEM,YOKOHAMA,KANAGAWA 223,JAPAN
来源：
TETRAHEDRON LETTERS | 1997年 / 38卷 / 27期
关键词：
D O I：
10.1016/S0040-4039(97)01035-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The enantiomerically pure synthesis or 9-[2',3'-dideoxy-2-'3'-bis-C-hydrosymethyl-alpha-L-threorunnosyl]adenine and its 4'-thio analog was achieved via coupling or silylated 6-chloropurine with 1-O-acetyfuranose derivative 17 and its 4'-thio analog 24, respectively, prepared from (+)-diethyl L-tartrate. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：4795 / 4798
页数：4
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