Synthesis of 9-[2',3'-dideoxy-2',3'-bis-C-hydroxymethyl-alpha-L-threofuranosyl] adenine and its 4'-thio analog as potential antiviral agents

被引：13

作者：

Kikuchi, Y

Kurata, H

Nishiyama, S

Yamamura, S

Kato, K

机构：

[1] NIPPON KAYAKU CO LTD,PHARMACEUT GRP,RES LABS,KITA KU,TOKYO 115,JAPAN

[2] KEIO UNIV,FAC SCI & TECHNOL,DEPT CHEM,YOKOHAMA,KANAGAWA 223,JAPAN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 27期

关键词：

D O I：

10.1016/S0040-4039(97)01035-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantiomerically pure synthesis or 9-[2',3'-dideoxy-2-'3'-bis-C-hydrosymethyl-alpha-L-threorunnosyl]adenine and its 4'-thio analog was achieved via coupling or silylated 6-chloropurine with 1-O-acetyfuranose derivative 17 and its 4'-thio analog 24, respectively, prepared from (+)-diethyl L-tartrate. (C) 1997 Elsevier Science Ltd.

引用

页码：4795 / 4798

页数：4

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