Computational challenges of systems biology

被引：43

作者：

Finkelstein, A ^{[1
]}

Hetherington, J ^{[1
]}

Li, LZ ^{[1
]}

Margoninski, O ^{[1
]}

Saffrey, P ^{[1
]}

Seymour, R ^{[1
]}

Warner, A ^{[1
]}

机构：

[1] UCL, London WC1E 6BT, England

来源：

COMPUTER | 2004年 / 37卷 / 05期

关键词：

D O I：

10.1109/MC.2004.1297236

中图分类号：

TP3 [计算技术、计算机技术];

学科分类号：

0812 ;

摘要：

By posing novel computational challenges and stretching the state of the art, bioinformatics has become the computing response to the molecular revolution in biology. But bioinformatics is only the first step in reshaping the life sciences. For further progress we must return to the study of whole biological systems: the heart, cardiovascular system, brain, and liver. Progress in systems biology will require computer scientists to work closely with life scientists and mathematicians. In contrast to the molecular biology revolution, computer science will actively engage in shaping systems biology. The prize to be attained is immense, ranging from in silico drug design and testing to individualized medicine that takes into account physiology and genetic profiles.

引用

页码：26 / +

页数：9

共 50 条

[21] Aging and computational systems biology
Mooney, Kathleen M.
Morgan, Amy E.
Mc Auley, Mark T.
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE, 2016, 8 (02) : 123 - 139
[22] Computational systems biology for toxicology
Mendes, Pedro
TOXICOLOGY LETTERS, 2014, 229 : S13 - S13
[23] Toward computational systems biology
You, LC
CELL BIOCHEMISTRY AND BIOPHYSICS, 2004, 40 (02) : 167 - 184
[24] Computational systems biology of aging
Kriete, Andres
Lechner, Mark
Clearfield, Drew
Bohmann, Dirk
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE, 2011, 3 (04) : 414 - 428
[25] Computational Models in Systems Biology
Chen, Xue-wen
2009 IEEE INTERNATIONAL CONFERENCE ON GRANULAR COMPUTING ( GRC 2009), 2009, : 1 - 1
[26] Toward computational systems biology
Lingchong You
Cell Biochemistry and Biophysics, 2004, 40 : 167 - 184
[27] Computational Inference in Systems Biology
Macdonald, Benn
Husmeier, Dirk
BIOINFORMATICS AND BIOMEDICAL ENGINEERING (IWBBIO 2015), PT II, 2015, 9044 : 276 - 288
[28] India's Computational Biology Growth and Challenges
Chakraborty, Chiranjib
Bandyopadhyay, Sanghamitra
Agoramoorthy, Govindasamy
INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES, 2016, 8 (03) : 263 - 276
[29] The Center for Computational Biology: resources, achievements, and challenges
Toga, Arthur W.
Dinov, Ivo D.
Thompson, Paul M.
Woods, Roger P.
Van Horn, John D.
Shattuck, David W.
Parker, D. Stott
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION, 2012, 19 (02) : 202 - 206
[30] India’s Computational Biology Growth and Challenges
Chiranjib Chakraborty
Sanghamitra Bandyopadhyay
Govindasamy Agoramoorthy
Interdisciplinary Sciences: Computational Life Sciences, 2016, 8 : 263 - 276

← 1 2 3 4 5 →