Enhanced dendritic morphogenesis of adult hippocampal newborn neurons in central 5-HT-deficient mice

被引：12
|
作者：
Song, Ning-Ning [1 ]
Zhang, Qiong [1 ]
Huang, Ying [1 ]
Chen, Ling [1 ]
Ding, Yu-Qiang [1 ,2 ]
Zhang, Lei [1 ,2 ]
机构：
[1] Tongji Univ Sch Med, East Hosp, Minist Educ China, Key Lab Arrhythmias, Shanghai 200120, Peoples R China
[2] Tongji Univ Sch Med, Collaborat Innovat Ctr Brain Sci, Dept Anat & Neurobiol, Shanghai 200092, Peoples R China
来源：
STEM CELL RESEARCH | 2017年 / 19卷
基金：
中国国家自然科学基金;
关键词：
Serotonin; Adult neurogenesis; Hippocampus; Dendrite; Dentate gyrus; CENTRAL SEROTONIN; NEUROGENESIS; PLASTICITY; CELL; RAT;
D O I：
10.1016/j.scr.2016.12.018
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Serotonin (5-HT) plays an important role in regulating adult hippocampal neurogenesis. Chronic administration of selective 5-HT reuptake inhibitors (SSRIs), which up-regulates extracellular 5-HT concentration, accelerates the maturation of adult-born hippocampal neurons. It is unknown, however, about effects of central 5-HT-deficiency on the dendritic morphogenesis of these newborn neurons. Here, we address this question using two central 5-HT-deficient mouse models, Tph2 conditional knockout mice (CKO) losing central 5-HT from embryonic stage, and Pet1-Cre;Rosa26-DTR (diphtheria toxin receptor) mice lacking central 5-HT neurons exclusively in adulthood. The dendritic length of hippocampal newborn neurons is dramatically increased in these mice. Our findings indicate that reducing central 5-HT can accelerate the dendritic maturation of adult-born neurons, thus revealing a new role of central 5- HT in regulating adult hippocampal neurogenesis. (C) 2016 The Authors. Published by Elsevier B.V.
引用
收藏
页码：6 / 11
页数：6
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