Anti-Mullerian Hormone and Its Clinical Use in Pediatrics with Special Emphasis on Disorders of Sex Development

被引：52

作者：

Johansen, Marie Lindhardt ^{[1
]}

Hagen, Casper P. ^{[1
]}

Johannsen, Trine Holm ^{[1
]}

Main, Katharina M. ^{[1
]}

Picard, Jean-Yves ^{[2
,3
]}

Jorgensen, Anne ^{[1
]}

Rajpert-De Meyts, Ewa ^{[1
]}

Juul, Anders ^{[1
]}

机构：

[1] Univ Copenhagen, Fac Med & Hlth Sci, Rigshosp 5064, Dept Growth & Reprod,GR, DK-2100 Copenhagen, Denmark

[2] INSERM, Res Unit, U782, F-92140 Clamart, France

[3] Univ Paris 11, F-92140 Clamart, France

来源：

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY | 2013年 / 2013卷

关键词：

GRANULOSA-CELL TUMOR; POLYCYSTIC-OVARY-SYNDROME; INHIBITING SUBSTANCE; ANTIMULLERIAN HORMONE; SERUM-LEVELS; HYPOGONADOTROPIC HYPOGONADISM; TURNER SYNDROME; KLINEFELTER-SYNDROME; EXPRESSION PATTERN; FOLLICLE COUNT;

D O I：

10.1155/2013/198698

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Using measurements of circulating anti-Mullerian hormone (AMH) in diagnosing and managing reproductive disorders in pediatric patients requires thorough knowledge on normative values according to age and gender. We provide age-and sex-specific reference ranges for the Immunotech assay and conversion factors for the DSL and Generation II assays. With this tool in hand, the pediatrician can use serum concentrations of AMH when determining the presence of testicular tissue in patients with bilaterally absent testes or more severe Disorders of Sex Development (DSD). Furthermore, AMH can be used as a marker of premature ovarian insufficiency (POI) in both Turner Syndrome patients and in girls with cancer after treatment with alkylating gonadotoxic agents. Lastly, its usefulness has been proposed in the diagnosis of polycystic ovarian syndrome (PCOS) and ovarian granulosa cell tumors and in the evaluation of patients with hypogonadotropic hypogonadism.

引用

页数：10

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