Calixarene: The Dawn of a New Era in Forensic Chemistry

Globally, rapid, ultrasensitive, and ultraselective detection of forensic evidence is critically required for social security and support. In the past four decades, calixarenes have been the focus of intensive research in the invention of several extractants, transporters, stationary phases, electrode ionophores, and optical and electrochemical sensors. This review is ardent about calixarene, a new class of selective and sensitive forensic sensors. It has become clear that calix[n]arenes are particularly attractive building blocks for supramolecular chemistry due to their synthesis on a large scale, distinctive concave molecular architecture, tunable inner cavity size, exceptional derivatization capabilities, and a broad range of applications. This paper opens up new avenues for the creation of on-site detection kits for forensic evidence, which will speed up the detection procedure.