Study of Sample Preparation Method Using Internal Standard Solution to Accurate Quantitative Analysis with 1H NMR Spectroscopy

被引:7
|
作者
Yamazaki, Taichi [1 ]
Ohtsuki, Takashi [2 ]
Miura, Toru [3 ]
Suematsu, Takako [4 ]
Horinouchi, Takaaki [5 ]
Murakami, Masayo [1 ]
Saito, Takeshi [1 ]
Ihara, Toshihide [1 ]
Tada, Atsuko [2 ]
Tahara, Maiko [2 ]
Goda, Yukihiro [2 ]
Akiyama, Hiroshi [2 ]
Nakao, Shinji [3 ]
Yamada, Yuko [3 ]
Koike, Ryo [5 ]
Sugimoto, Naoki [2 ]
机构
[1] Natl Inst Adv Ind Sci & Technol, NMIJ, Tsukuba, Ibaraki 3058563, Japan
[2] Natl Inst Hlth Sci, Setagaya Ku, Tokyo 1588501, Japan
[3] Wako Pure Chem Ind Ltd, Kawagoe, Saitama 3501101, Japan
[4] JEOL RESONANCE Inc, Akishima, Tokyo 1968558, Japan
[5] Kao Corp, Wakayama 6408580, Japan
关键词
quantitative NMR; standard solution; H-1; NMR;
D O I
10.2116/bunsekikagaku.63.323
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Since nuclear magnetic resonance (NMR) spectroscopy obtains a quantitative value on the basis of a nucleus, the quantitative NMR technique does not require an identical standard. For this reason, it is expected to be a universal quantitative method. Recently, the quantitative NMR method was adopted also as a regulating method. However, the quantification using an NMR requires a high-resolution balance in the sample preparation for accurate weighing of the mass of samples. This is the biggest problems to disseminate a quantitative NMR as a generally used method. In this paper, we discuss the quantitative NMR method using the internal standard solution in order to resolve the problem. We examined two methods of sample preparation: the gravimetric method and the volumetric method. The influence of the preparation method and condition was evaluated using a standard solution. Additionally, some organizations have used this method to measure the purity of a high-purity reference material for the validation of this standard solution method. The accuracy of the results was evaluated using an internal standard solution by the volumetric method, and measured at 1 % or less.
引用
收藏
页码:323 / 329
页数:7
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