Total Synthesis of the Ambigols: A Cyanobacterial Class of Polyhalogenated Natural Products

被引：7

作者：

Milzarek, Tobias M. ^{[1
]}

Gulder, Tobias A. M. ^{[1
]}

机构：

[1] Tech Univ Dresden, Chair Tech Biochem, D-01069 Dresden, Germany

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 01期

关键词：

CHLORINATED DIPHENYL ETHERS; TOXICOLOGICAL ASSESSMENT; DIARYLIODONIUM SALTS; CHEMISTRY; IDENTIFICATION; BIOSYNTHESIS; POTENT;

D O I：

10.1021/acs.orglett.0c03784

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of all members of the cyanobacterial natural product class of the ambigols is described. Key steps of the synthetic strategy are the formation of sterically demanding mono- and bis-iodonium salts to install the required biaryl ether structural elements and Suzuki cross-coupling giving straightforward access to the biaryl bonds. The synthetic methods are also utilized to construct unnatural or hypothetical ambigols that are still awaiting discovery from Nature.

引用

页码：102 / 106

页数：5

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