Human endogenous retrovirus-H long terminal repeat-associating 2: The next immune checkpoint for antitumour therapy

被引：15
|
作者：
Ying, Honggang [1 ,2 ,3 ,4 ,5 ]
Xu, Jian [1 ,2 ,3 ,4 ,5 ]
Zhang, Xiaozhen [1 ,2 ,3 ,4 ,5 ]
Liang, Tingbo [1 ,2 ,3 ,4 ,5 ]
Bai, Xueli [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Hepatobiliary & Pancreat Surg, Hangzhou 310003, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Zhejiang Prov Key Lab Pancreat Dis, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China
[3] Zhejiang Prov Innovat Ctr Study Pancreat Dis, Hangzhou 310003, Zhejiang, Peoples R China
[4] Zhejiang Prov Clin Res Ctr Study Hepatobiliary &, Hangzhou 310003, Zhejiang, Peoples R China
[5] Zhejiang Univ, Canc Ctr, Hangzhou 310058, Zhejiang, Peoples R China
来源：
EBIOMEDICINE | 2022年 / 79卷
基金：
中国国家自然科学基金;
关键词：
HHLA2; TMIGD2; KIR3DL3; Immune checkpoint; Cancer immunotherapy; B7; FAMILY-MEMBER; CANCER-IMMUNOTHERAPY; PROGNOSTIC-SIGNIFICANCE; CELL-ADHESION; HHLA2; IDENTIFICATION; EXPRESSION; SURVIVAL; IGPR-1; OVEREXPRESSION;
D O I：
10.1016/j.ebiom.2022.103987
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Human endogenous retrovirus-H long terminal repeat-associating 2 (HHLA2) is a newly emerging immune checkpoint that belongs to B7 family. HHLA2 has a co-stimulatory receptor transmembrane and immunoglobulin domain containing 2 (TMIGD2) and a newly discovered co-inhibitory receptor killer cell Ig-like receptor, three Ig domains, and long cytoplasmic tail (KIR3DL3), which endows it with both immunostimulant and immunosuppression functions in cancer development. In this review, we summarize the HHLA2 expression profile in human cancers, its association with cancer prognosis and clinical features, and its dual roles in regulating cancer immune response through up-to-date literatures. Furthermore, we highlight that precision cancer immunotherapy through manipulating HHLA2-KIR3DL3/TMIGD2 interaction is a promising antitumour strategy.
引用
收藏
页数：11
相关论文
共 34 条
  • [31] The long terminal repeat of ERV-9 human endogenous retrovirus located in the 5'boundary area of the β-globin locus control region exhibits enhancer activity during oogenesis, early embryogenesis and hematopoiesis in transgenic zebrafish
    Pi, WH
    Yang, ZA
    Ruan, L
    Ling, JH
    Yu, XP
    Isales, C
    Lin, S
    Tuan, D
    BLOOD, 2002, 100 (11) : 32B - 33B
  • [32] NUCLEOTIDE-SEQUENCE OF THE LONG TERMINAL REPEAT AND FLANKING CELLULAR SEQUENCES OF AVIAN ENDOGENOUS RETROVIRUS-EV-2 - VARIATION IN ROUS-ASSOCIATED VIRUS-0 EXPRESSION CANNOT BE EXPLAINED BY DIFFERENCES IN PRIMARY SEQUENCE
    SCHOLL, DR
    KAHN, S
    MALAVARCA, R
    ASTRIN, S
    SKALKA, AM
    JOURNAL OF VIROLOGY, 1983, 45 (02) : 868 - 871
  • [33] THE PROMOTER OF THE LONG TERMINAL REPEAT OF FELINE LEUKEMIA-VIRUS IS EFFECTIVE FOR EXPRESSION OF A MOUSE H-2 HISTOCOMPATIBILITY GENE IN MOUSE AND HUMAN-CELLS
    WONG, TC
    GOODENOW, RS
    SHER, BT
    DAVIDSON, N
    GENE, 1985, 34 (01) : 27 - 38
  • [34] p53 Binding Sites in Long Terminal Repeat 5Hs (LTR5Hs) of Human Endogenous Retrovirus K Family (HML-2 Subgroup) Play Important Roles in the Regulation of LTR5Hs Transcriptional Activity
    Liu, Mengying
    Jia, Lei
    Li, Hanping
    Liu, Yongjian
    Han, Jingwan
    Wang, Xiaolin
    Li, Tianyi
    Li, Jingyun
    Zhang, Bohan
    Zhai, Xiuli
    Yu, Changyuan
    Li, Lin
    MICROBIOLOGY SPECTRUM, 2022, 10 (04):
1234