It has recently been noted that the relative prevalence of the various kinds of epistasis varies along an adaptive walk. This has been explained as a result of mean regression in NK model fitness landscapes. Here we show that this phenomenon occurs quite generally in fitness landscapes. We propose a simple and general explanation for this phenomenon, confirming the role of mean regression. We provide support for this explanation with simulations, and discuss the empirical relevance of our findings.
机构:
City Hope Natl Med Ctr, Div Nursing Res, 1500 East Duarte Rd, Duarte, CA 91010 USACity Hope Natl Med Ctr, Div Nursing Res, 1500 East Duarte Rd, Duarte, CA 91010 USA
Ferrell, Betty R.
Smith, Thomas
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Johns Hopkins Canc Ctr, Palliat Med & Oncol, Baltimore, MD USACity Hope Natl Med Ctr, Div Nursing Res, 1500 East Duarte Rd, Duarte, CA 91010 USA
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
MIT, Dept Biol, Cambridge, MA 02142 USA
MIT, Howard Hughes Med Inst, Cambridge, MA 02142 USA
Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA
Harvard Univ, Howard Hughes Med Inst, Cambridge, MA 02138 USAWhitehead Inst Biomed Res, Cambridge, MA 02142 USA
Curtis, Edward A.
Bartel, David P.
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Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
MIT, Dept Biol, Cambridge, MA 02142 USA
MIT, Howard Hughes Med Inst, Cambridge, MA 02142 USAWhitehead Inst Biomed Res, Cambridge, MA 02142 USA
机构:
Xi An Jiao Tong Univ, Sch Management, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
Hong Kong Polytech Univ, Dept Ind & Syst Engn, Kowloon, Hong Kong, Peoples R ChinaXi An Jiao Tong Univ, Sch Management, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
Li, G.
Ji, P.
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Hong Kong Polytech Univ, Dept Ind & Syst Engn, Kowloon, Hong Kong, Peoples R ChinaXi An Jiao Tong Univ, Sch Management, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
Ji, P.
Sun, L. Y.
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Xi An Jiao Tong Univ, Sch Management, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R ChinaXi An Jiao Tong Univ, Sch Management, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
Sun, L. Y.
Lee, W. B.
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Hong Kong Polytech Univ, Dept Ind & Syst Engn, Kowloon, Hong Kong, Peoples R ChinaXi An Jiao Tong Univ, Sch Management, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China