The Changing Geometry of a Fitness Landscape Along an Adaptive Walk

被引：33
|
作者：
Greene, Devin [1 ]
Crona, Kristina [1 ]
机构：
[1] Univ Calif Merced, Merced, CA 95343 USA
来源：
PLOS COMPUTATIONAL BIOLOGY | 2014年 / 10卷 / 05期
关键词：
BENEFICIAL MUTATIONS; SIGN EPISTASIS; EVOLUTION; MODEL;
D O I：
10.1371/journal.pcbi.1003520
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
It has recently been noted that the relative prevalence of the various kinds of epistasis varies along an adaptive walk. This has been explained as a result of mean regression in NK model fitness landscapes. Here we show that this phenomenon occurs quite generally in fitness landscapes. We propose a simple and general explanation for this phenomenon, confirming the role of mean regression. We provide support for this explanation with simulations, and discuss the empirical relevance of our findings.
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页数：10
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