Synthesis of novel derivatives of 4-methylbenzimidazole and evaluation of their biological activities

4-Methylbenzimidazole 1-28 novel derivatives were synthesized and evaluated for their antiglycation and antioxidant activities. Compounds 1-7 and 11 showed excellent activities ranged 140-280 mu M, better than standard drug rutin (294.46 +/- 1.50 mu M). Compound 1-28 were also evaluated for DPPH activities. Compounds 1-8 showed excellent activities, ranging 12-29 mu M, better than standard drug n-propylgallate (IC50 = 30.30 +/- 0.40 mu M). For superoxide anion scavenging activity, compounds 1-7 showed better activity than standard n-propylgallate (IC50 = 106.34 +/- 1.6 mu M), ranged 82-104 mu M. These compounds were found to be nontoxic to THP-1 cells. (C) 2014 Elsevier Masson SAS. All rights reserved.