Non-coding RNA-mediated epigenetic regulation of liver fibrosis

被引：43
|
作者：
Yang, Jingling [1 ]
Tao, Hui [2 ]
Deng, Zi-Yu [4 ]
Lu, Chao [4 ]
Li, Jun [3 ]
机构：
[1] Anhui Med Univ, Hosp 2, Dept Pharmacol, Hefei 230601, Peoples R China
[2] Anhui Med Univ, Hosp 2, Dept Cardiothorac Surg, Hefei 230601, Peoples R China
[3] Anhui Med Univ, Sch Pharm, Hefei 230032, Anhui, Peoples R China
[4] Anhui Med Univ, Hosp 2, Dept Sci & Educ, Hefei 230601, Peoples R China
来源：
METABOLISM-CLINICAL AND EXPERIMENTAL | 2015年 / 64卷 / 11期
关键词：
Epigenetic; MicroRNA; Long non-coding RNA; Liver fibrosis; Hepatic stellate cell; HEPATIC STELLATE CELLS; TISSUE GROWTH-FACTOR; DNA METHYLATION; STEM-CELLS; MESENCHYMAL TRANSITION; INHIBITS PROLIFERATION; CLINICAL-SIGNIFICANCE; SIGNALING PATHWAY; BINDING-PROTEIN; EXPRESSION;
D O I：
10.1016/j.metabol.2015.08.004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hepatic stellate cells (HSC) activation plays a key role in liver fibrosis. Numerous studies have indicated that non-coding RNAs (ncRNAs) control liver fibrosis and fibroblasts proliferation. Greater knowledge of the role of the ncRNAs-mediated epigenetic mechanism in liver fibrosis could improve understanding of the liver fibrosis pathogenesis. The aim of this review is to describe the present knowledge about the ncRNAs significantly participating in liver fibrosis and HSC activation, and look ahead on new perspectives of ncRNAs-mediated epigenetic mechanism research. Moreover, we will discuss examples of non-coding RNAs that interact with histone modification or DNA methylation to regulate gene expression in liver fibrosis. Diverse classes of ncRNAs, ranging from microRNAs (miRs) to long non-coding RNAs (LncRNAs), have emerged as key regulators of several important aspects of function, including cell proliferation, activation, etc. In addition, recent advances suggest the important role of ncRNAs transcripts in epigenetic gene regulation. Targeting the miRs and LncRNAs can be a promising direction in liver fibrosis treatment. We discuss new perspectives of miRs and LncRNAs in liver fibrosis and FISC activation, mainly including interaction with histone modification or DNA methylation to regulate gene expression. These epigenetic mechanisms form powerful ncRNAs surveillance systems that may represent new targets for liver fibrosis therapeutic intervention. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：1386 / 1394
页数：9
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