MicroRNAs: Novel Regulators During the Immune Response

被引：138
|
作者：
Bi, Yujing [1 ]
Liu, Guangwei [2 ]
Yang, Ruifu [1 ]
机构：
[1] Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Lab Analyt Microbiol, Beijing 100071, Peoples R China
[2] Chinese Acad Sci, State Key Lab Biomembrane & Membrane Biotechnol, Transplantat Biol Res Div, Beijing, Peoples R China
来源：
JOURNAL OF CELLULAR PHYSIOLOGY | 2009年 / 218卷 / 03期
基金：
中国国家自然科学基金;
关键词：
TOLL-LIKE RECEPTORS; B-CELL DEVELOPMENT; C-ELEGANS; T-CELLS; MICROPROCESSOR COMPLEX; INFLAMMATORY RESPONSE; EXPRESSION PROFILES; NUCLEAR EXPORT; RAPID CHANGES; GENE;
D O I：
10.1002/jcp.21639
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
MicroRNAs (miRNAs), an abundant class of highly conversed, small noncoding RNAs, present an entirely new way of post-transcriptional gone regulation. miRNAs play a key role in diverse biological processes, such as embryogenesis, differentiation, inflammation, viral infections, and carcinogenesis. Recently, more studios showed the importance of these noncoding small RNAs on immune system development and response, and miRNAs are found to involve in the regulation of immunity, including the development and differentiation of immune cells, antibody production and the inflammatory mediator release. I fore, the latest findings were summarized to explore the function and mechanism of miRNAs in modulating innate and adaptive immune responses.
引用
收藏
页码：467 / 472
页数：6
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