Synthesis of Substituted α-Trifluoromethyl Piperidinic Derivatives

被引：8

作者：

Rioton, Sarah ^{[1
]}

Pardo, Domingo Gomez ^{[1
]}

Cossy, Janine ^{[1
]}

机构：

[1] PSL Res Univ, ESPCI Paris, CNRS UMR 8231, Inst Chem Biol & Innovat CBI,Lab Chim Organ, 10 Rue Vauquelin, F-75231 Paris 05, France

来源：

MOLECULES | 2017年 / 22卷 / 03期

关键词：

nitrogen heterocycles; fluorine; piperidine; trifluoromethyl group; ring expansion; cyclization; cycloaddition; RING-CLOSING METATHESIS; AMINO-ACID-DERIVATIVES; MULTICOMPONENT SYNTHESIS; STEREOSELECTIVE ACCESS; ASYMMETRIC-SYNTHESIS; OLEFIN METATHESIS; CYCLIC IMINES; ONE-POT; HETEROCYCLES; REARRANGEMENT;

D O I：

10.3390/molecules22030483

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A comprehensive survey of pathways leading to the generation of alpha-trifluoromethyl monocyclic piperidinic derivatives is provided (65 references). These compounds have been synthesized either from 6-membered rings e.g., pipecolic acid or lactam derivatives by introduction a trifluoromethyl group, from pyridine or pyridinone derivatives by reduction, and from 5-membered rings e.g., prolinol derivatives by ring expansion, from linear amines by cyclization or from dienes/dienophiles by [4 + 2]-cycloaddition.

引用

页数：22

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