Activation of the rat scavenger receptor class B type I gene by PPARα

被引：22

作者：

Lopez, Dayarni

McLean, Mark P.

机构：

[1] Univ S Florida, Coll Med, Dept Obstet & Gynecol, Tampa, FL 33612 USA

[2] Univ S Florida, Coll Med, Dept Biochem & Mol Biol, Tampa, FL 33612 USA

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2006年 / 251卷 / 1-2期

关键词：

fibrates; peroxisomal proliferator activated receptor alpha; retinoid X receptor; peroxisomal proliferator-response element; scavenger receptor class B type I;

D O I：

10.1016/j.mce.2006.02.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Peroxisomal proliferator activated receptor alpha (PPAR alpha) is activated by fibrate drugs which are known to protect against atherosclerosis. The present study examines the effects of PPARa on SR-BI expression. For this study, a rat SR-BI promoter-luciferase reporter gene construct was co-transfected into different cell lines with expression vectors that encode for PPAR alpha retinoic X receptor alpha (RXR alpha). PPAR alpha/RXR increased the activity of the SR-BI promoter, an effect that was enhanced by clofibrate. Sequence analysis of the rat SR-BI promoter revealed the presence of a putative peroxisomal proliferator response element (PPRE) at bp - 1622. Electrophoretic mobility shift assays demonstrated that PPAR alpha and RXRa are able to bind to the SR-BI PPRE motif. In addition, mutational analysis studies confirmed that this PPRE motif is responsible for the PPAR alpha/RXR alpha-dependent activation of the rat SR-BI promoter in the cell lines examined. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：67 / 77

页数：11

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