Reversible conformational changes in the parallel type G-quadruplex structure inside a thermoresponsive hydrogel

被引：20
|
作者：
Hasuike, Erika [1 ,2 ]
Akimoto, Aya Mizutani [1 ]
Kuroda, Reiko [3 ]
Matsukawa, Ko [1 ]
Hiruta, Yuki [2 ]
Kanazawa, Hideko [2 ]
Yoshida, Ryo [1 ]
机构：
[1] Univ Tokyo, Dept Mat Engn, Sch Engn, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan
[2] Keio Univ, Fac Pharm, Tokyo, Japan
[3] Tokyo Univ Sci, Res Inst Sci & Technol, Chiba, Japan
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 21期
基金：
日本学术振兴会;
关键词：
CIRCULAR-DICHROISM; DNA APTAMER; ADENOSINE; BINDING; SALT; GELS;
D O I：
10.1039/c7cc00279c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The novel property of reversible regulation of parallel type G-quadruplexes with moderate temperature changes was discovered in thermoresponsive hydrogels using a universal chiroptical spectrophotometer 1 (UCS-1). This study is the first to report the regulation of the ssDNA steric structure by using a poly(N-isopropylacrylamide) (PNIPAAm) gel.
引用
收藏
页码：3142 / 3144
页数：3
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