Reversible conformational changes in the parallel type G-quadruplex structure inside a thermoresponsive hydrogel

被引：20

作者：

Hasuike, Erika ^{[1
,2
]}

Akimoto, Aya Mizutani ^{[1
]}

Kuroda, Reiko ^{[3
]}

Matsukawa, Ko ^{[1
]}

Hiruta, Yuki ^{[2
]}

Kanazawa, Hideko ^{[2
]}

Yoshida, Ryo ^{[1
]}

机构：

[1] Univ Tokyo, Dept Mat Engn, Sch Engn, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan

[2] Keio Univ, Fac Pharm, Tokyo, Japan

[3] Tokyo Univ Sci, Res Inst Sci & Technol, Chiba, Japan

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 21期

基金：

日本学术振兴会;

关键词：

CIRCULAR-DICHROISM; DNA APTAMER; ADENOSINE; BINDING; SALT; GELS;

D O I：

10.1039/c7cc00279c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The novel property of reversible regulation of parallel type G-quadruplexes with moderate temperature changes was discovered in thermoresponsive hydrogels using a universal chiroptical spectrophotometer 1 (UCS-1). This study is the first to report the regulation of the ssDNA steric structure by using a poly(N-isopropylacrylamide) (PNIPAAm) gel.

引用

页码：3142 / 3144

页数：3

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