MicroRNA-187 Inhibits Growth and Metastasis of Osteosarcoma by Downregulating S100A4

被引：29

作者：

Xiao, Yi ^{[1
]}

Zhao, Quan ^{[2
]}

Du, Bo ^{[3
]}

Chen, Hua-yan ^{[1
]}

Zhou, Dao-Zheng ^{[1
]}

机构：

[1] Peoples Hosp Kaizhou Dist, Dept Orthopaed, Chongqing, Peoples R China

[2] Peoples Hosp Kaizhou Dist, Dept Med Imaging, Chongqing 405400, Peoples R China

[3] Peoples Hosp Kaizhou Dist, Dept Gen Surg, Chongqing, Peoples R China

来源：

CANCER INVESTIGATION | 2018年 / 36卷 / 01期

关键词：

miR-187; Osteosarcoma; S100A4; Proliferation; metastasis; CANCER; MIRNAS; CARCINOMA; SIRNAS;

D O I：

10.1080/07357907.2017.1415348

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Abnormal expression and dysfunction of microRNAs are correlated with osteosarcoma (OS). This study demonstrated that the miR-187 level in OS tissues and cell lines was decreased. The proliferation and metastatic abilities of U-2OS cells were inhibited by miR-187 overexpression and promoted by miR-187 knockdown. Moreover, miR-187 also inhibited growth and metastasis of OS cells in vivo. Furthermore, we revealed that miR-187 could interact with S100A4 3-UTR and inhibit S100A4 expression in OS cells. In summary, miR-187 inhibits growth and metastasis of OS cells by downregulating S100A4, which might be a potential biomarker and therapeutic target of OS.

引用

页码：1 / 9

页数：9

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