SYNTHESIS OF 2-(4-METHOXY-PHENYL)-3-(9-METHYL-5,6-DIHYDRO-4H-3-THIA-1-AZA-BENZO[E]AZULEN-2-YL)-THIAZOLIDIN-4-ONE AND DERIVATIVES FROM BENZOSUBERONES

被引：0
|
作者：
Bathini, Srinivas [1 ]
Sadhvik, B. [1 ]
机构：
[1] Srizanta Bio Lab, Res & Dev, Hyderabad 500048, Telangana, India
来源：
HETEROCYCLIC LETTERS | 2019年 / 9卷 / 03期
关键词：
benzosuberone; thiazolidinone; fungicides; bactericide; type 2 diabetes mellitus; POTENTIAL FUNGICIDES;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reaction of 2-methyl-6,7,8,9-tetrahydrobenzocyclohepten-5-one (1) with hydrogen bromide and hydrogen peroxide gave 6-bromo-2-methyl-6,7,8,9-tetrahydrobenzocyclohepten-5-one (2). The compound 2 on cycloaddition with thiourea gave 5,6-dihydro-4H-benzo[6,7]cycloheptane[d][2,3]thiazol-2-amine (3). Compound 3, when treated with various aromatic aldehydes in absolute ethanol and a few drops of glacial acetic acid, resulted the corresponding enamine derivatives 4a-f. Compounds 4a-f on cyclocondensation with thioglycolic acid in the presence of anhydrous zinc chloride resulting in the formation of thiazolidinone ring systems 5a-f. [GRAPHICS] .
引用
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页码：273 / 277
页数：5
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