AGE-RELATED SYNAPTIC CHANGES IN THE CA1 STRATUM RADIATUM AND SPATIAL LEARNING IMPAIRMENT IN RATS

被引：22
|
作者：
Long, Li-Hong [1 ,2 ,3 ]
Liu, Rui-Li [1 ]
Wang, Fang [1 ,2 ,3 ]
Liu, Jue [1 ]
Hu, Zhuang-Li [1 ,2 ,3 ]
Xie, Na [1 ,2 ,3 ]
Jin, You [1 ,2 ,3 ]
Fu, Hui [1 ,2 ,3 ]
Chen, Jian-Guo [1 ,2 ,3 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Pharmacol, Wuhan 430030, Hubei, Peoples R China
[2] Minist Educ China, Key Lab Neurol Dis, Wuhan, Peoples R China
[3] Hubei Key Lab Neurol Dis, Wuhan, Peoples R China
来源：
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2009年 / 36卷 / 07期
基金：
中国国家自然科学基金; 美国国家科学基金会;
关键词：
ageing; autophosphorylated Ca2+; calmodulin-dependent protein kinase II at threonine 286 (pThr286-alpha CaMKII); cognitive deficits; synapses; LONG-TERM POTENTIATION; KINASE-II; POSTSYNAPTIC DENSITIES; ALZHEIMERS-DISEASE; MEMORY DECLINE; PROTEIN-KINASE; AGING BRAIN; LATE-PHASE; HIPPOCAMPAL; DEFICITS;
D O I：
10.1111/j.1440-1681.2008.05132.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
P>Age-related impairments in hippocampus-dependent spatial learning and memory are not associated with a loss of neurons, but may be related to synaptic changes. In the present study, we analysed the behavioural performance of adult, middle-aged and old Wistar rats using the Morris water maze, as well as the structure of synapses and the expression of autophosphorylated Ca2+/calmodulin-dependent protein kinase II at threonine 286 (pThr286-alpha CaMKII), a key post-synaptic protein in the CA1 stratum radiatum, in the same rats. Old Wistar rats showed significant cognitive deficits. Synaptic density, the area of post-synaptic densities and the total number of synapses in the CA1 stratum radiatum of old rats were significantly decreased compared with adult rats. The decrease in autophosphorylated pThr286-alpha CaMKII was age dependent. These findings reveal that age-related impairments in learning and memory are associated with synaptic atrophy. The decreased expression of pThr286-CaMKII may result in reduced synaptic function with ageing.
引用
收藏
页码：675 / 681
页数：7
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