The current research status of normal tension glaucoma

被引：38

作者：

Mi, Xue-Song ^{[1
,2
]}

Yuan, Ti-Fei ^{[3
,4
]}

So, Kwok-Fai ^{[2
,4
,5
]}

机构：

[1] Jinan Univ, Affiliated Hosp 1, Dept Ophthalmol, Guangzhou 510632, Guangdong, Peoples R China

[2] Univ Hong Kong, Li Ka Shing Fac Med, Dept Anat, Hong Kong, Hong Kong, Peoples R China

[3] Nanjing Normal Univ, Sch Psychol, Nanjing, Jiangsu, Peoples R China

[4] Univ Hong Kong, Li Ka Shing Fac Med, Dept Ophthalmol, Hong Kong, Hong Kong, Peoples R China

[5] Jinan Univ, GHM Inst CNS Regenerat, Guangzhou 510632, Guangdong, Peoples R China

来源：

CLINICAL INTERVENTIONS IN AGING | 2014年 / 9卷

关键词：

aging; genetics; neurovascular unit; primary open-angle glaucoma; treatment; OPEN-ANGLE GLAUCOMA; BLOOD-BRAIN-BARRIER; OPTIC-NERVE HEAD; PROGRESSIVE RETINAL DEGENERATION; AMYLOID PRECURSOR PROTEIN; CENTRAL CORNEAL THICKNESS; VISUAL-FIELD PROGRESSION; GANGLION-CELL FATE; INTRAOCULAR-PRESSURE; ALZHEIMERS-DISEASE;

D O I：

10.2147/CIA.S67263

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Normal tension glaucoma (NTG) is a progressive optic neuropathy that mimics primary open-angle glaucoma, but lacks the findings of elevated intraocular pressure or other mitigating factors that can lead to optic neuropathy. The present review summarized the causes, genetics, and mechanisms underlying NTG in both animal models and human patients. We also proposed that the neurovascular unit is a therapeutic target for NTG management.

引用

页码：1563 / 1571

页数：9

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