Genomic imprinting and its role in Prader-Willi and Angelman syndromes

被引：0
|
作者：
Mglinets, VA
Levina, LY
Konstantinova, LM
机构：
来源：
GENETIKA | 1996年 / 32卷 / 12期
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D O I：
暂无
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Published and our own data, included in the CHRODYS database, on the dependence of phenotypic abnormalities in mono-, di-, and trisomics at human chromosome 15 on its parental origin are reviewed. The concept is confirmed that Prader-Willi and Angelman syndromes result from the combined effect of gene or chromosome mutations impairing the expression of syndrome-specific genes and from genomic imprinting, i.e., repression of corresponding genes received from one of the parents.
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页码：1605 / 1615
页数：11
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