In vitro cyto-biocompatibility and cell detachment of temperature-sensitive dextran hydrogel

被引：31
|
作者：
Xiao, Fei [1 ]
Chen, Li [1 ]
Xing, Rui-Feng [1 ]
Zhao, Yi-Ping [1 ]
Dong, Jing [1 ]
Guo, Gang [2 ]
Zhang, Rui [2 ]
机构：
[1] Tianjin Polytech Univ, Sch Mat Sci & Chem Engn, Tianjin Key Lab Fiber Modificat & Funct Fiber, Tianjin 300160, Peoples R China
[2] Tianjin Med Univ, Inst Endocrinol, Tianjin 300070, Peoples R China
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2009年 / 71卷 / 01期
关键词：
Hydrogels; N-Isopropylacrylamide; Dextran; Temperature-sensitivity; Cell culture; DRUG-DELIVERY; IMMOBILIZATION;
D O I：
10.1016/j.colsurfb.2008.12.040
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
A series of poly(NIPAAm-co-GMA-Dex) hydrogels were synthesized from glycidyl methacrylate-derivatized dextran (GMA-Dex) and N-isopropylacrylamide (NIPAAm) in aqueous solution. The swelling properties, cell culture and detachment behaviors of these hydrogels were investigated. It has found that poly(NIPAAm-co-GMA-Dex) hydrogels are not only sensitive to temperature in deionized water and Dulbecco's modified eagle medium (DMEM) (10% FBS), but also exhibit good biocompatibility. In addition, L929 cells were found to detach from the hydrogel surface naturally without affecting the function of L929 by controlling environmental temperature. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：13 / 18
页数：6
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