Total synthesis of luminacin D

被引：24

作者：

Shotwell, JB

Krygowski, ES

Hines, J

Koh, B

Huntsman, EWD

Choi, HW

Schneekloth, JS

Wood, JL

Crews, CM ^{[1
]}

机构：

[1] Yale Univ, Dept Chem, Sterling Chem Lab, New Haven, CT 06520 USA

[2] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

[3] Yale Univ, Dept Pharmacol, New Haven, CT 06520 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 18期

关键词：

D O I：

10.1021/ol026382q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A highly convergent synthesis of the angiogenesis inhibitor luminacin D has been achieved in 13 linear steps (19 steps total, 5.3% overall yield) utilizing a samarium(II) iodide-mediated mixed tandem aldol/Evans-Tishchenko reaction to construct the carbohydrate precursor. The modular synthetic design will allow derivatization at key positions necessary for biochemical mode of action studies.

引用

页码：3087 / 3089

页数：3

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