A Role for Histone Acetylation in the Developmental Regulation of V(D)J Recombination

被引：233

作者：

McMurry, Michelle Taylor ^{[1
]}

Krangel, Michael S. ^{[1
]}

机构：

[1] Duke Univ, Dept Immunol, Med Ctr, POB 3010, Durham, NC 27710 USA

来源：

JOURNAL OF IMMUNOLOGY | 2017年 / 199卷 / 01期

关键词：

DELTA-GENE REARRANGEMENT; NUCLEOSOMAL DNA; ALPHA-ENHANCER; HYPERACETYLATION; ACCESSIBILITY; CLEAVAGE; MICE; H4;

D O I：

10.1126/science.287.5452.495

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

V(D)J recombination is developmentally regulated in vivo by enhancer -dependent changes in the accessibility of chromosomal recombination signal sequences to the recombinase, but the molecular nature of these changes is unknown. Here histone H3 acetylation was measured along versions of a transgenic V(D)J recombination reporter and the endogenous T cell receptor alpha/delta locus. Enhancer activity was shown to impart tong-range, developmentally regulated changes in H3 acetylation, and H3 acetylation status was tightly linked to V(D)J recombination. H3 hyperacetylation is proposed as a molecular mechanism coupling enhancer activity to accessibiLity for V(D)J recombination.

引用

页码：5 / 8

页数：4

共 50 条

[41] V(D)J recombination
Schatz, DG
IMMUNOLOGICAL REVIEWS, 2004, 200 : 5 - 11
[42] V(D)J recombination
Sekiguchi, J
Frank, K
CURRENT BIOLOGY, 1999, 9 (22) : R835 - R835
[43] V(D)J recombination: RAG proteins, repair factors, and regulation
Gellert, M
ANNUAL REVIEW OF BIOCHEMISTRY, 2002, 71 : 101 - 132
[44] The role of histone acetylation in transcriptional regulation and seed development
Chen, Yan
Guo, Peiguo
Dong, Zhicheng
PLANT PHYSIOLOGY, 2024, 194 (04) : 1962 - 1979
[45] A Role of Histone Acetylation in the Regulation of Circadian Rhythm in Ants
Libbrecht, Romain
Nadrau, Dennis
Foitzik, Susanne
ISCIENCE, 2020, 23 (02)
[46] V(D)J recombination, somatic hypermutation and class switch recombination of immunoglobulins: mechanism and regulation
Chi, Xiying
Li, Yue
Qiu, Xiaoyan
IMMUNOLOGY, 2020, 160 (03) : 233 - 247
[47] Role of ATM in V(D)J recombination and cell cycle control
Dujka, Melanie E.
Puebla-Osorio, Nahum
Zhu, Chengming
JOURNAL OF IMMUNOLOGY, 2007, 178
[48] Role of RAG1 autoubiquitination in V(D)J recombination
Singh, Samarendra K.
Gellert, Martin
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (28) : 8579 - 8583
[49] V(D)J recombination RAG recombination centres
Leavy, Olive
NATURE REVIEWS IMMUNOLOGY, 2010, 10 (06) : 383 - 383
[50] A role for secondary V(D)J recombination in oncogenic chromosomal translocations?
Davila, M
Foster, S
Kelsoe, G
Yang, KY
ADVANCES IN CANCER RESEARCH, VOL 81, 2001, 81 : 61 - 92

← 1 2 3 4 5 →