Cyclophilin A and EMMPRIN (CD147) in cardiovascular diseases

被引：73
|
作者：
Seizer, Peter [1 ]
Gawaz, Meinrad [1 ]
May, Andreas E. [1 ]
机构：
[1] Univ Tubingen, Med Klin 3, Kardiol & Kreislauferkrankungen, D-72076 Tubingen, Germany
来源：
CARDIOVASCULAR RESEARCH | 2014年 / 102卷 / 01期
关键词：
EMMPRIN; Cyclophilin A; Inflammation; METALLOPROTEINASE INDUCER EMMPRIN; LOW-DENSITY LIPOPROTEINS; CD4(+) T-CELLS; EXTRACELLULAR CYCLOPHILIN; CYCLOSPORINE-A; INFLAMMATION; PLATELETS; EXPRESSION; SECRETION; MONOCYTES;
D O I：
10.1093/cvr/cvu035
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cyclophilin A(CyPA) is an abundantly expressed intracellular protein. It exerts a variety of functions due to its peptidyl-prolylcis-trans isomerase (PPIase) activity. When released into the extracellular space, CyPA binds to its extracellular receptor CD147 (EMMPRIN) and thereby initiates a cascade of inflammatory processes. Recent data indicate that both extra-and intracellular CyPA significantly contribute to cardiovascular inflammation, myocardial ischaemia and reperfusion injury, and myocardial remodelling processes. Thus, CyPA appears to represent a novel target to treat vascular and myocardial inflammation.
引用
收藏
页码：17 / 23
页数：7
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