Effect of Retinopathy of Prematurity on Scotopic Spatial Summation

PURPOSE. To evaluate scotopic retinal organization in retinopathy of prematurity (ROP) through a study of spatial summation. METHODS. Thresholds for a range of stimulus diameters (0.4 degrees-10 degrees) were measured using a two alternative, spatial, forced choice psychophysical procedure. The critical diameter (D-CRIT) for complete summation was estimated in subjects with a history of severe ROP (N = 7) and mild ROP (N = 17). Subjects who were born preterm and never had ROP (N = 16) and term-born subjects (N = 7) were also tested. The subjects ranged in age from 9 to 17 (median 13.5) years. RESULTS. Critical diameter for complete spatial summation was significantly larger in ROP subjects than in subjects who never had ROP and in term-born control subjects. Critical diameter varied significantly with severity of ROP. CONCLUSIONS. The larger DCRIT values in ROP are consistent with altered organization of the post receptor retina. This may offer the ROP retina a strategy for achieving noise reduction and good dark-adapted visual sensitivity.