Two's company but three's a blast!

被引:2
|
作者
Iskander, Deena [1 ]
机构
[1] Imperial Coll London, London, England
关键词
ERYTHROBLASTIC ISLAND; ERYTHROPOIESIS; STRESS;
D O I
10.1182/blood.2022017644
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In this issue of Blood, Romano et al discover that in murine bone marrow, both granulocyte and erythroid precursors develop around a single central macrophage, within a specialized niche termed erythromyeloblastic islands (EMBI).1 Although it is well established that mammalian erythropoiesis occurs in erythroblastic islands (EBI), comprising 5 to 30 maturing red blood cell precursors surrounding a macrophage,2 like an orchestra around a conductor, Romano et al identify that the "orchestra" constitutes granulocyte as well as erythroid precursors. Furthermore, they introduce a new concept in hematopoietic cell homeostasis: an inverse relationship between erythroid and granulocyte lineage cell numbers in EMBI that vary in response to microenvironmental cues. These findings provide insight into disorders such as anemia of inflammation/chronic disease.
引用
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页码:1578 / 1580
页数:4
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