A novel synthesis of arylpyrrolo[1,2-a]pyrazinone derivatives

被引：7

作者：

Wang, F ^{[1
]}

Wang, JW ^{[1
]}

Zhang, SF ^{[1
]}

机构：

[1] Shanyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China

来源：

MOLECULES | 2004年 / 9卷 / 07期

关键词：

aryl-2-methyl-1-pyrrolo[1,2-a]pyrazinones; synthesis; anti-inflammation;

D O I：

10.3390/90700574

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Some aryl-2-methyl-1-pyrrolo[1,2-a]pyrazinones were designed and prepared to study the Structure-Activity Relationships (SAR) of pyrrolo[1,2-a]pyrazinone derivatives. With methyl pyrrole-2-carboxylate as the starting material, the title compounds were prepared through N-alkylation and two novel cyclizations. Eleven aryl-2-methyl-1-pyrrolo[1,2-a]pyrazinone derivatives not previously reported in the literature are presented in this paper. Some of them show potent anti-inflammatory and analgesic activities.

引用

页码：574 / 582

页数：9

共 50 条

[21] Synthesis of new derivatives of pyrido[1,2-a]triazine
V. V. Dotsenko
S. G. Krivokolysko
V. P. Litvinov
Chemistry of Heterocyclic Compounds, 2007, 43 (4) : 517 - 518
[22] SYNTHESIS AND APPLICATION OF IMIDAZOLE DERIVATIVES - SYNTHESIS OF PYRIDO[1,2-A]BENZIMIDAZOLONE DERIVATIVES
OHTA, S
YUASA, T
NARITA, Y
KAWASAKI, I
MINAMII, E
YAMASHITA, M
HETEROCYCLES, 1991, 32 (10) : 1923 - 1931
[23] SYNTHESIS AND STUDY OF IMIDAZO[1,2-A]IMIDAZOLE DERIVATIVES
IVASHCHENKO, AV
LAZAREVA, VT
SHMELEV, LV
POPONOVA, RV
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1982, (03): : 384 - 387
[24] Photochemical synthesis of pyrimido[1,2-a]benzimidazole derivatives
Frolov, AN
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2004, 74 (12) : 1949 - 1951
[25] SYNTHESIS OF IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AND THEIR REACTIONS
IDE, S
KATOU, K
ITOU, T
MOTOKAWA, C
CHIYOMARU, Y
MATSUDA, Y
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1993, 113 (12): : 861 - 869
[26] SYNTHESIS OF PYRIDO(1,2-A) PYRIDINE-DERIVATIVES
BINIECKI, S
MODRZEJEWSKA, W
ACTA POLONIAE PHARMACEUTICA, 1984, 41 (06): : 607 - 611
[27] Synthesis of Spiro Derivatives of Pyrrolo[1,2-a]quinoline
T. V. Glukhareva
E. V. D'yachenko
Yu. Yu. Morzherin
Chemistry of Heterocyclic Compounds, 2002, 38 (11) : 1426 - 1427
[28] A novel synthesis of imidazo[1,2-a]quinoxalines
A. Poursattar Marjani
J. Khalafy
R. H. Prager
Chemistry of Heterocyclic Compounds, 2012, 48 : 931 - 935
[29] NEW SYNTHESIS OF PYRROLO[1,2-A]INDOLE DERIVATIVES
RYABOVA, SY
GRANIK, VG
MENDELEEV COMMUNICATIONS, 1992, (02) : 59 - 60
[30] Synthesis of pyrrolo[1,2-a]quinoline spiro derivatives
Glukhareva, TV
D'yachenko, EV
Morzherin, YY
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 2002, (11): : 1610 - 1611

← 1 2 3 4 5 →