A novel synthesis of arylpyrrolo[1,2-a]pyrazinone derivatives

被引：7
|
作者：
Wang, F [1 ]
Wang, JW [1 ]
Zhang, SF [1 ]
机构：
[1] Shanyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China
来源：
MOLECULES | 2004年 / 9卷 / 07期
关键词：
aryl-2-methyl-1-pyrrolo[1,2-a]pyrazinones; synthesis; anti-inflammation;
D O I：
10.3390/90700574
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Some aryl-2-methyl-1-pyrrolo[1,2-a]pyrazinones were designed and prepared to study the Structure-Activity Relationships (SAR) of pyrrolo[1,2-a]pyrazinone derivatives. With methyl pyrrole-2-carboxylate as the starting material, the title compounds were prepared through N-alkylation and two novel cyclizations. Eleven aryl-2-methyl-1-pyrrolo[1,2-a]pyrazinone derivatives not previously reported in the literature are presented in this paper. Some of them show potent anti-inflammatory and analgesic activities.
引用
收藏
页码：574 / 582
页数：9
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