Combined Targeting of mTORC1 and mTORC2 Synergistically Inhibits Proliferation of Hepatocellular Carcinoma Cells: Effects of Everolimus and Ku0063794

被引：0
|
作者：
Kim, Say-June
Choi, Ho-Joong
Kim, Dong-Goo
机构：
[1] Catholic Univ Korea, Dept Surg, Daejeon St Marys Hosp, Taejon, South Korea
[2] Catholic Univ Korea, Buchen St Marys Hosp, Dept Surg, Puchon, South Korea
[3] Catholic Univ Korea, Seoul St Marys Hosp, Dept Surg, Seoul, South Korea
来源：
LIVER TRANSPLANTATION | 2014年 / 20卷
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
P-268
引用
收藏
页码：S235 / S235
页数：1
相关论文
共 50 条
  • [41] Effective and selective targeting of glioblastoma multiforme using an active-site inhibitor of mTORC1/mTORC2 kinase
    Neil, Jayson
    Shannon, Craig
    Tobias, Michael
    Braun, Alex
    Murali, Raj
    Jhanwar-Uniyal, Meena
    CANCER RESEARCH, 2012, 72
  • [42] A dual mTORC1 and mTORC2 inhibitor shows antitumor activity in esophageal squamous cell carcinoma cells and sensitizes them to cisplatin
    Huang, Yu
    Xi, Qingsong
    Chen, Yu
    Wang, Jing
    Peng, Ping
    Xia, Shu
    Yu, Shiying
    ANTI-CANCER DRUGS, 2013, 24 (09) : 889 - 898
  • [43] mTORC1 and mTORC2 play different roles in regulating cardiomyocyte differentiation from embryonic stem cells
    Zheng, Bei
    Wang, Jiadan
    Tang, Leilei
    Shi, Jiana
    Zhu, Danyan
    INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2017, 61 (1-2): : 65 - 72
  • [44] Superior cellular anti-tumor effects of a dual mTORC1/mTORC2 kinase inhibitor OXA-01 relative to the mTORC1 inhibitor rapamycin
    Bhagwat, Shripad
    Crew, Andrew
    Gokhale, Prafulla
    Yao, Yan
    Kahler, Jennifer
    Arnold, Lee
    Epstein, David
    Wild, Robert
    Pachter, Jonathan
    CANCER RESEARCH, 2009, 69
  • [45] The Combined Inhibition of SREBP and mTORC1 Signaling Synergistically Inhibits B-Cell Lymphoma
    Zhu, Zhenhan
    Jiang, Wenxia
    Zhou, Jiehao
    Maldeney, Alexander Robert
    Liang, Jingru
    Yang, Jing
    Luo, Wei
    CANCER MEDICINE, 2024, 13 (21):
  • [46] Radiation response of glioblastoma cell lines after combined mTORC1 and mTORC2 inhibition by PP242
    Staus, M.
    Qureischi, M.
    Polat, B.
    Flentje, M.
    Djuzenova, C. S.
    STRAHLENTHERAPIE UND ONKOLOGIE, 2014, 190 : 45 - 45
  • [47] mTORC1 and mTORC2 differentially regulate homeostasis of neoplastic and non-neoplastic human mast cells
    Smrz, Daniel
    Kim, Mi-Sun
    Zhang, Shuling
    Mock, Beverly A.
    Smrzova, Sarka
    DuBois, Wendy
    Simakova, Olga
    Maric, Irina
    Wilson, Todd M.
    Metcalfe, Dean D.
    Gilfillan, Alasdair M.
    BLOOD, 2011, 118 (26) : 6803 - 6813
  • [48] Differential functions of mTORC1 and mTORC2 in the maintenance of stem-like properties of pancreatic cancer cells
    Matsubara, Shyuichiro
    Tsukasa, Koichiro
    Kuwahata, Taisaku
    Obara, Toru
    Matsuyama, Takami
    Takao, Sonshin
    CANCER SCIENCE, 2018, 109 : 703 - 703
  • [49] The dual mTORC1 and mTORC2 inhibitor AZD8055 inhibits head and neck squamous cell carcinoma cell growth in vivo and in vitro
    Li, Qiang
    Song, Xin-mao
    Ji, Yang-yang
    Jiang, Hui
    Xu, Lin-gen
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 440 (04) : 701 - 706
  • [50] NOD2 inhibits tumorigenesis and increases chemosensitivity of hepatocellular carcinoma by targeting LKB1/AMPK/mTORC1 axis
    Ma, X.
    Qiu, Y.
    Zhu, L.
    Lin, Y.
    Han, L.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 44 - 44
12345