Combined Targeting of mTORC1 and mTORC2 Synergistically Inhibits Proliferation of Hepatocellular Carcinoma Cells: Effects of Everolimus and Ku0063794

被引：0
|
作者：
Kim, Say-June
Choi, Ho-Joong
Kim, Dong-Goo
机构：
[1] Catholic Univ Korea, Dept Surg, Daejeon St Marys Hosp, Taejon, South Korea
[2] Catholic Univ Korea, Buchen St Marys Hosp, Dept Surg, Puchon, South Korea
[3] Catholic Univ Korea, Seoul St Marys Hosp, Dept Surg, Seoul, South Korea
来源：
LIVER TRANSPLANTATION | 2014年 / 20卷
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
P-268
引用
收藏
页码：S235 / S235
页数：1
相关论文
共 50 条
  • [1] A COMPARISON OF KU0063794, A DUAL MTORC1 AND MTORC2 INHIBITOR, AND TEMSIROLIMUS IN PRECLINICAL RENAL CELL CARCINOMA MODELS
    Zhang, Hao
    Berel, Dror
    Wang, Yanping
    Figlin, Robert
    Kim, Hyung
    JOURNAL OF UROLOGY, 2012, 187 (04): : E121 - E122
  • [2] A Comparison of Ku0063794, a Dual mTORC1 and mTORC2 Inhibitor, and Temsirolimus in Preclinical Renal Cell Carcinoma Models
    Zhang, Hao
    Berel, Dror
    Wang, Yanping
    Li, Ping
    Bhowmick, Neil A.
    Figlin, Robert A.
    Kim, Hyung L.
    PLOS ONE, 2013, 8 (01):
  • [3] KU0063794, a Dual mTORC1 and mTORC2 Inhibitor, Reduces Neural Tissue Damage and Locomotor Impairment After Spinal Cord Injury in Mice
    Marika Cordaro
    Irene Paterniti
    Rosalba Siracusa
    Daniela Impellizzeri
    Emanuela Esposito
    Salvatore Cuzzocrea
    Molecular Neurobiology, 2017, 54 : 2415 - 2427
  • [4] KU0063794, a Dual mTORC1 and mTORC2 Inhibitor, Reduces Neural Tissue Damage and Locomotor Impairment After Spinal Cord Injury in Mice
    Cordaro, Marika
    Paterniti, Irene
    Siracusa, Rosalba
    Impellizzeri, Daniela
    Esposito, Emanuela
    Cuzzocrea, Salvatore
    MOLECULAR NEUROBIOLOGY, 2017, 54 (04) : 2415 - 2427
  • [5] Dramatic antitumor effects of the dual mTORC1 and mTORC2 inhibitor AZD2014 in hepatocellular carcinoma
    Liao, Hui
    Huang, Yu
    Guo, Botang
    Liang, Bo
    Liu, Xincheng
    Ou, Huohui
    Jiang, Chenglong
    Li, Xianghong
    Yang, Dinghua
    AMERICAN JOURNAL OF CANCER RESEARCH, 2015, 5 (01): : 125 - 139
  • [6] Potentiation of the anticancer effects of everolimus using a dual mTORC1/2 inhibitor in hepatocellular carcinoma cells
    Kim, Jong-Ok
    Kim, Kee-Hwan
    Song, In Sang
    Cheon, Kwang-Sik
    Kim, Ok-Hee
    Lee, Sang Chul
    Lee, Sang Kuon
    Kim, Say-June
    ONCOTARGET, 2017, 8 (02) : 2936 - 2948
  • [7] PEBP4 Directs the Malignant Behavior of Hepatocellular Carcinoma Cells via Regulating mTORC1 and mTORC2
    Chen, Qiongfeng
    Jin, Jingguang
    Guo, Wenhui
    Tang, Zhimin
    Luo, Yunfei
    Ying, Ying
    Lin, Hui
    Luo, Zhijun
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (15)
  • [8] Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
    Luo, Yan
    Liu, Lei
    Wu, Yang
    Singh, Karnika
    Su, Bing
    Zhang, Nan
    Liu, Xiaowei
    Shen, Yangmei
    Huang, Shile
    ONCOTARGET, 2015, 6 (06) : 4286 - 4298
  • [9] mTORC1 and mTORC2 differentially regulate the development of NK cells
    Yang, Chao
    Siebert, Jason
    Thakar, Monica
    Malarkannan, Subramaniam
    JOURNAL OF IMMUNOLOGY, 2018, 200 (01):
  • [10] Predominance of mTORC1 over mTORC2 in the Regulation of Proliferation of Ovarian Cancer Cells: Therapeutic Implications
    Carlos Montero, Juan
    Chen, Xi
    Ocana, Alberto
    Pandiella, Atanasio
    MOLECULAR CANCER THERAPEUTICS, 2012, 11 (06) : 1342 - 1352
12345