Non-Alloimmune Mechanisms of Thrombocytopenia and Refractoriness to Platelet Transfusion

被引：6
|
作者：
Belizaire, Roger [1 ]
Makar, Robert S. [2 ]
机构：
[1] Brigham & Womens Hosp, Adult Transfus Med, 75 Francis St, Boston, MA 02115 USA
[2] Massachusetts Gen Hosp, Blood Transfus Serv, GRJ 2233,55 Fruit St, Boston, MA 02114 USA
来源：
TRANSFUSION MEDICINE REVIEWS | 2020年 / 34卷 / 04期
关键词：
Thrombocytopenia; Platelet transfusion; Refractoriness; Infection; Inflammation; VON-WILLEBRAND-FACTOR; HELICOBACTER-PYLORI ERADICATION; FACTOR-CLEAVING PROTEASE; TUMOR-NECROSIS-FACTOR; IN-VIVO; ENDOTHELIAL GLYCOCALYX; AMINOCAPROIC ACID; SEVERE SEPSIS; IMMUNE THROMBOCYTOPENIA; STAPHYLOCOCCUS-AUREUS;
D O I：
10.1016/j.tmrw.2020.09.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Refractoriness to platelet transfusion is a common clinical problem encountered by the transfusion medicine specialist. It is well recognized that most causes of refractoriness to platelet transfusion are not a consequence of alloimmunization to human leukocyte, platelet-specific, or ABO antigens, but are a consequence of platelet sequestration and consumption. This review summarizes the clinical factors that result in platelet refractoriness and highlights recent data describing novel biological mechanisms that contribute to this clinical problem. (C) 2020 Published by Elsevier Inc.
引用
收藏
页码：242 / 249
页数：8
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