Solubility and degradation of paracetamol in subcritical water

被引:17
|
作者
Emire, Zuhal [1 ]
Yabalak, Erdal [1 ]
Goermez, Zkan [1 ]
Gizir, Ahmet Murat [1 ]
机构
[1] Mersin Univ, Fac Arts & Sci, Dept Chem, Ciftlikkoy Campus, TR-TR33343 Mersin, Turkey
关键词
subcritical water medium; approximation model; paracetamol; degradation; solubility; RESPONSE-SURFACE METHODOLOGY; ADVANCED OXIDATION PROCESSES; WASTE-WATER; DRINKING-WATER; PHARMACEUTICALS; REMOVAL; ACID; EXTRACTION; SAND; DECOMPOSITION;
D O I
10.2298/JSC160520079E
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In this study, solubility and degradation of paracetamol were examined using subcritical water. The effect of temperature and static time was investigated during the solubility process in subcritical water at constant pressure (50 bar). The experimental results showed that temperature and static time have crucial effects on the degradation and solubility degrees. The maximal solubility of paracetamol was obtained at 403 K as (14.68 +/- 0.74) x 10(3). An approximation model for the solubility of paracetamol was proposed. O-2 and H2O2 were used for the degradation of paracetamol. The maximum degradation degree was found as 68.66 +/- 1.05 % and 100 +/- 0.00 % using O-2 and H2O2, respectively.
引用
收藏
页码:99 / 106
页数:8
相关论文
共 50 条
  • [31] THERMODYNAMICS OF PARACETAMOL SOLUBILITY IN SUGAR-WATER COSOLVENT SYSTEMS
    ETMAN, MA
    NAGGAR, VF
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1990, 58 (03) : 177 - 184
  • [32] Degradation of benzoic acid and its derivatives in subcritical water
    Lindquist, Edward
    Yang, Yu
    JOURNAL OF CHROMATOGRAPHY A, 2011, 1218 (15) : 2146 - 2152
  • [33] Hydrolytic degradation of monomer casting nylon in subcritical water
    Wang, Wei
    Meng, Linghui
    Huang, Yudong
    POLYMER DEGRADATION AND STABILITY, 2014, 110 : 312 - 317
  • [34] Degradation kinetics of passion fruit pectin in subcritical water
    Klinchongkon, Khwanjai
    Khuwijitjaru, Pramote
    Adachi, Shuji
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2017, 81 (04) : 712 - 717
  • [35] Degradation of crosslinked unsaturated polyesters by using subcritical water
    Suyama, Kanji
    Kubota, Masafumi
    Shirai, Masamitsu
    Yoshida, Hiroyuki
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 233
  • [36] Degradation of Soy Sauce Cake by Subcritical Water Treatment
    Fujii, Tatsuya
    Take, Shintaro
    Hayashi, Rumiko
    Oshima, Yoshito
    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, 2012, 45 (01) : 34 - 40
  • [37] Degradation kinetics of dihydroxyacetone and glyceraldehyde in subcritical and supercritical water
    Kabyemela, BM
    Adschiri, T
    Malaluan, R
    Arai, K
    INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 1997, 36 (06) : 2025 - 2030
  • [38] Experimental study and modeling of letrozole (anticancer drug) solubility in subcritical water: Production of nanoparticles using subcritical water precipitation method
    Mohammadi, Hadi Share
    Asl, Ali Haghighi
    Khajenoori, Maryam
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2022, 67
  • [39] Experimental solubility of omeprazole in pure and ethanol-modified subcritical water
    Salehian, Meysam
    Asl, Ali Haghighi
    Khajenoori, Maryam
    SCIENTIFIC REPORTS, 2024, 14 (01):
  • [40] Solubility and solution thermodynamic properties of quercetin and quercetin dihydrate in subcritical water
    Srinivas, Keerthi
    King, Jerry W.
    Howard, Luke R.
    Monrad, Jeana K.
    JOURNAL OF FOOD ENGINEERING, 2010, 100 (02) : 208 - 218