Cytokeratins - Clinical utility in breast cancer

被引：0
|
作者：
Barak, V [1 ]
Nisman, B [1 ]
Hubert, A [1 ]
Lyass, O [1 ]
Peretz, T [1 ]
机构：
[1] Hadassah Univ Hosp, Dept Oncol, Immunol Lab Tumor Diagnosis, IL-12000 Jerusalem, Israel
来源：
JOURNAL OF CLINICAL LIGAND ASSAY | 2002年 / 25卷 / 01期
关键词：
cytokeratins; TPS; breast cancer; prognosis; monitoring;
D O I：
暂无
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Cytokeratins belong to the intermediate filament protein family which is a component of the cytoskeleton of epithelial cells. The most abundant cytokeratins present in epithelial tumors are cytokeratins 8,18, and 19. TPA, TPS, and CYFRA 21-1, based on fragments of these cytokeratins, are the three cytokeratin markers in clinical use today. They are mainly used for treatment monitoring in cancer patients, but also for diagnosis (in lung carcinoma) and for prognosis in several types of cancers, especially in breast cancer.
引用
收藏
页码：40 / 42
页数：3
相关论文
共 50 条
  • [31] Utility of the Breast Cancer Index (BCI) in the clinical practice.
    Kodali, Saranya
    Tipirneni, Eswar
    Dittus, Kim
    JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)
  • [32] Prediction and clinical utility of a contralateral breast cancer risk model
    Daniele Giardiello
    Ewout W. Steyerberg
    Michael Hauptmann
    Muriel A. Adank
    Delal Akdeniz
    Carl Blomqvist
    Stig E. Bojesen
    Manjeet K. Bolla
    Mariël Brinkhuis
    Jenny Chang-Claude
    Kamila Czene
    Peter Devilee
    Alison M. Dunning
    Douglas F. Easton
    Diana M. Eccles
    Peter A. Fasching
    Jonine Figueroa
    Henrik Flyger
    Montserrat García-Closas
    Lothar Haeberle
    Christopher A. Haiman
    Per Hall
    Ute Hamann
    John L. Hopper
    Agnes Jager
    Anna Jakubowska
    Audrey Jung
    Renske Keeman
    Iris Kramer
    Diether Lambrechts
    Loic Le Marchand
    Annika Lindblom
    Jan Lubiński
    Mehdi Manoochehri
    Luigi Mariani
    Heli Nevanlinna
    Hester S. A. Oldenburg
    Saskia Pelders
    Paul D. P. Pharoah
    Mitul Shah
    Sabine Siesling
    Vincent T. H. B. M. Smit
    Melissa C. Southey
    William J. Tapper
    Rob A. E. M. Tollenaar
    Alexandra J. van den Broek
    Carolien H. M. van Deurzen
    Flora E. van Leeuwen
    Chantal van Ongeval
    Laura J. Van’t Veer
    Breast Cancer Research, 21
  • [33] Clinical utility of fulvestrant in the treatment of breast cancer: a report on the emerging clinical evidence
    Rocca, Andrea
    Maltoni, Roberta
    Bravaccini, Sara
    Donati, Caterina
    Andreis, Daniele
    CANCER MANAGEMENT AND RESEARCH, 2018, 10 : 3083 - 3099
  • [34] Clinical validity and clinical utility of Ki67 in early breast cancer
    Kreipe, Hans
    Harbeck, Nadia
    Christgen, Matthias
    THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2022, 14
  • [35] Clinical Utility of Universal Germline Genetic Testing for Patients With Breast Cancer
    Whitworth, Pat W.
    Beitsch, Peter D.
    Patel, Rakesh
    Rosen, Barry
    Compagnoni, Gia
    Baron, Paul L.
    Simmons, Rache
    Brown, Eric A.
    Gold, Linsey
    Holmes, Dennis
    Smith, Linda Ann
    Kinney, Michael
    Grady, Ian
    Clark, Patricia
    Barbosa, Karen
    Lyons, Samuel
    Riley, Lee
    Coomer, Cynara
    Curcio, Lisa
    Ruiz, Antonio
    Khan, Sadia
    MacDonald, Heather
    Hughes, Kevin
    Hardwick, Mary Kay
    Heald, Brandie
    Munro, Sandra B.
    Nielsen, Sarah M.
    Esplin, Edward D.
    JAMA NETWORK OPEN, 2022, 5 (09) : E2232787
  • [36] Clinical utility of measuring circulating tumor cells in metastatic breast cancer
    Guarneri, Valentina
    Cristofanilli, Massimo
    CLINICAL BREAST CANCER, 2006, 7 (01) : 85 - 86
  • [37] THE CLINICAL UTILITY OF CARCINOEMBRYONIC ANTIGEN (CEA) DETERMINATIONS IN BREAST-CANCER
    VILLANI, C
    MINERVA MEDICA, 1981, 72 (49) : 3315 - 3322
  • [38] The Long and Winding Road for Breast Cancer Biomarkers to Reach Clinical Utility
    Hunter, Natasha B.
    Kilgore, Mark R.
    Davidson, Nancy E.
    CLINICAL CANCER RESEARCH, 2020, 26 (21) : 5543 - 5545
  • [39] Triple negative breast cancer (TNBC): clinical utility of immunohistochemical classification
    Perez-Lopez, M.
    Arias, M.
    Penin, M.
    Garcia-Mata, J.
    Garcia-Caballero, T.
    BREAST, 2015, 24 : S40 - S40
  • [40] Clinical utility of frozen section in sentinel node biopsy in breast cancer
    Gulec, SA
    Su, J
    O'Leary, JP
    Stolier, A
    AMERICAN SURGEON, 2001, 67 (06) : 529 - 532
12345