Next Generation Sequencing in Non-Small Cell Lung Cancer: Pitfalls and Opportunities

被引：19
|
作者：
Lazzari, Chiara [1 ]
Bulotta, Alessandra [1 ]
Cangi, Maria Giulia [2 ]
Bucci, Gabriele [3 ]
Pecciarini, Lorenza [2 ]
Bonfiglio, Silvia [3 ]
Lorusso, Vincenza [1 ,2 ]
Ippati, Stefania [1 ]
Arrigoni, Gianluigi [2 ]
Grassini, Greta [2 ]
Doglioni, Claudio [2 ]
Gregorc, Vanesa [1 ]
机构：
[1] IRCCS San Raffaele, Dept Oncol, I-20132 Milan, Italy
[2] IRCCS San Raffaele, Dept Pathol, I-20132 Milan, Italy
[3] IRCCS San Raffaele, Ctr Omics Sci, I-20132 Milan, Italy
来源：
DIAGNOSTICS | 2020年 / 10卷 / 12期
关键词：
non-small cell lung cancer; next-generation sequencing; molecular tumor board; BIOLOGY; DRUGS;
D O I：
10.3390/diagnostics10121092
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Lung cancer remains the first cause of cancer-related deaths worldwide. Thanks to the improvement in the knowledge of the biology of non-small cell lung cancer (NSCLC), patients' survival has significantly improved. A growing number of targetable molecular alterations have been identified. Next-generation sequencing (NGS) has become one of the methodologies entered in clinical practice and was recently recommended by the European society for medical oncology (ESMO) to perform a comprehensive molecular characterization in patients with cancer. The current review provides an overview of the clinical trials that have explored the impact of NGS in patients with cancer, its limits, and advantages.
引用
收藏
页数：12
相关论文
共 50 条
  • [21] Identification of rare gene fusions in non-small cell lung cancer with next-generation sequencing
    Zhuo, M.
    Gu, W.
    Chen, R.
    Yuan, M.
    ANNALS OF ONCOLOGY, 2021, 32 : S992 - S992
  • [22] Next generation sequencing techniques in liquid biopsy: focus on non-small cell lung cancer patients
    Malapelle, Umberto
    Pisapia, Pasquale
    Rocco, Danilo
    Smeraglio, Riccardo
    di Spirito, Maria
    Bellevicine, Claudio
    Troncone, Giancarlo
    TRANSLATIONAL LUNG CANCER RESEARCH, 2016, 5 (05) : 505 - 510
  • [23] Budget Impact of Next-Generation Sequencing for Molecular Assessment of Advanced Non-Small Cell Lung Cancer
    Yu, Tiffany M.
    Morrison, Carl
    Gold, Edward J.
    Tradonsky, Alison
    Arnold, Renee J. G.
    VALUE IN HEALTH, 2018, 21 (11) : 1278 - 1285
  • [24] Molecular Characterization of Non-Small Cell Lung Cancer (NSCLC) Patients by Next Generation Sequencing: Preliminary Data
    Wainsztein, V.
    Recondo, G.
    Denninghoff, V.
    Cuello, M. T.
    Greco, M.
    De La Vega, M.
    Galanternik, F.
    Rojas Bilbao, E.
    Avagnina, A.
    Castro, M.
    Recondo, G.
    JOURNAL OF THORACIC ONCOLOGY, 2018, 13 (09) : S168 - S169
  • [25] Simultaneous Detection of Gene Rearrangements and Variants in Non-Small Cell Lung Cancer by Next-Generation Sequencing
    Xu, Shuo
    Boag, Alexander
    Mates, Mihaela
    Chen, Lina
    Feilotter, Harriet
    MODERN PATHOLOGY, 2016, 29 : 487A - 487A
  • [26] Establishment of a diagnostic system using next generation sequencing for RET rearrangements in non-small cell lung cancer
    Matsumoto, S.
    Mimaki, S.
    Kohno, T.
    Tsuta, K.
    Tada, S.
    Goto, K.
    Yoh, K.
    Ohe, Y.
    Esumi, H.
    Tsuchihara, K.
    EUROPEAN JOURNAL OF CANCER, 2013, 49 : S139 - S139
  • [27] Next generation sequencing based targeted panel analysis in advanced non-small cell lung cancer (NSCLC)
    Erdamar, S.
    Barut, P.
    Eksioglu, A.
    Yakicier, C.
    Olcaysoy, B.
    Tokat, F.
    Ince, U.
    VIRCHOWS ARCHIV, 2021, 479 (SUPPL 1) : S135 - S135
  • [28] Next Generation Sequencing Reveals Genomic Heterogenity of ALK Fusion Breakpoints in Non-Small Cell Lung Cancer
    Rosenbaum, Jason N.
    Branson, Julie
    Cottrell, Catherine E.
    Pfeifer, John D.
    Kulkarm, Shashikant
    Duncavage, Eric J.
    MODERN PATHOLOGY, 2016, 29 : 481A - 482A
  • [29] Plasma CfDNA next Generation Sequencing in Non-Small Cell Lung Cancer: Clinical Outcomes and Comparison to Tissue
    Raez, L.
    Mekhail, T.
    Rodriguez, E.
    Hunis, B.
    Nashed, A.
    Dietrich, M.
    Nagy, R.
    Kiedrowski, L.
    JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (11) : S1862 - S1862
  • [30] Next-Generation Sequencing of Liquid-Based Cytology Non-Small Cell Lung Cancer Samples
    Reynolds, Jordan P.
    Zhou, Yaolin
    Jakubowski, Maureen A.
    Wang, Zhen
    Brainard, Jennifer A.
    Klein, Roger D.
    Farver, Carol F.
    Almeida, Francisco A.
    Cheng, Yu-Wei
    CANCER CYTOPATHOLOGY, 2017, 125 (03) : 178 - 187
12345