Receptor-dependent coronavirus infection of dendritic cells

被引：18
|
作者：
Turner, BC
Hemmila, EM
Beauchemin, N
Holmes, KV
机构：
[1] Univ Colorado, Ctr Hlth Sci, Dept Microbiol, Denver, CO 80262 USA
[2] McGill Univ, McGill Canc Ctr, Montreal, PQ, Canada
[3] McGill Univ, Dept Biochem, Montreal, PQ, Canada
[4] McGill Univ, Dept Med, Montreal, PQ, Canada
[5] McGill Univ, Dept Oncol, Montreal, PQ, Canada
来源：
JOURNAL OF VIROLOGY | 2004年 / 78卷 / 10期
关键词：
D O I：
10.1128/JVI.78.10.5486-5490.2004
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In several mammalian species, including humans, coronavirus infection can modulate the host immune response. We show a potential role of dendritic cells (DC) in murine coronavirus-induced immune modulation and pathogenesis by demonstrating that the JAW SII DC line and primary DC from BALB/c mice and p/p mice with reduced expression of the murine coronavirus receptor, murine CEACAM1a, are susceptible to murine coronavirus infection by a receptor-dependent pathway.
引用
收藏
页码：5486 / 5490
页数：5
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