Single-subject and statistical inference are virtually identical. With both techniques change is inferred when variability across conditions is sufficiently large to accommodate variability within conditions, replication is the final arbiter of whether change is likely to occur by chance, a large effect size is preferred to a small consistent difference, there are similar threats to internal validity, and generalizability of results is valued. Knowing how to use statistical inferential procedures would make behavior analysts more methodologically sophisticated. It would also help them to critically evaluate research in other areas of psychology, obtain research grants, and publish their research in diverse outlets, which would help others to see behavior-analytic work.