Preparation of amphiphilic magnetic polyvinyl alcohol targeted drug carrier and drug delivery research

被引：10
|
作者：
Wang, Yazhen [1 ,2 ,3 ]
Shi, Zhen [1 ,2 ]
Sun, Yu [2 ]
Wu, Xueying [2 ]
Li, Shuang [2 ]
Dong, Shaobo [2 ]
机构：
[1] Qiqihar Univ, Coll Mat Sci & Engn, Qiqihar 161006, Peoples R China
[2] Heilongjiang Prov Key Lab Polymer Composite Mat, Qiqihar, Peoples R China
[3] Northeast Forestry Univ, Coll Chem Chem Engn & Resource Utilizat, Harbin, Peoples R China
来源：
DESIGNED MONOMERS AND POLYMERS | 2020年 / 23卷 / 01期
关键词：
Fe3O4; magnetic; Poly(vinyl alcohol); targeted drug delivery; amphiphilic; IRON-OXIDE NANOPARTICLES; FE3O4; NANOPARTICLES; CONTROLLED-RELEASE; HYDROGEL; COMPOSITE; POLYMER; SYSTEM; ASPIRIN;
D O I：
10.1080/15685551.2020.1837442
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Currently, magnetic applications have great potential for development in the field of drug carriers. In this paper, Fe3O4-PVA@SH, an amphiphilic magnetically targeting drug carrier, was prepared by using Fe3O4 and PVA with thiohydrazide-iminopropyltriethoxysilane(TIPTS). The loading capacity of Fe3O4-PVA@SH on Aspirin and the drug release kinetics of loaded drugs were studied. The obtained Fe3O4-PVA@SH exhibits excellent drug release properties in simulating the human body fluid environment (pH 7.2). Since magnetically targeting drug carriers are readily available and have excellent biocompatibility and the characteristics of drug release. This work's development, preparing amphiphilic magnetically targeting drug carriers in drug delivery and other fields, has great significance.
引用
收藏
页码：197 / 206
页数：10
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